Inmunonutrición perioperatoria. Consenso de la Asociación Colombiana de Nutrición Clínica

Charles Bermúdez; Álvaro Sanabria; Juan Ayala; Andrés Becerra; Mauricio Chona; Liceloth Colpas; Ana Henao; Iván Katime; Lina López; Luis Marroquín; Ricardo Merchán; Martha Muñoz; Ángela Navas; Justo Olaya; Angélica Pérez; Fernando Pereira; Milena Puentes; Mario Rodríguez; Luisa Torres; Arturo Vergara

doi:10.35454/rncm.v2n1.055

Authors

Charles Bermúdez https://orcid.org/0000-0001-5401-019X
Álvaro Sanabria https://orcid.org/0000-0002-5563-8840
Juan Ayala https://orcid.org/0000-0002-7337-8026
Andrés Becerra https://orcid.org/0000-0002-7337-8026
Mauricio Chona
Liceloth Colpas
Ana Henao
Iván Katime
Lina López
Luis Marroquín
Ricardo Merchán https://orcid.org/0000-0002-7962-403X
Martha Muñoz
Ángela Navas
Justo Olaya https://orcid.org/0000-0002-8029-5560
Angélica Pérez
Fernando Pereira https://orcid.org/0000-0002-3823-2726
Milena Puentes https://orcid.org/0000-0002-0802-8345
Mario Rodríguez
Luisa Torres
Arturo Vergara

DOI:

https://doi.org/10.35454/rncm.v2n1.055

Keywords:

Surgery, Immunonutrition, Artificial nutrition, Nutritional care

Abstract

Immunonutrition is an alternative for surgical patients due to its clinical advantages. The aim is to unify the concepts and develop a document of easy access and quick consultation about immunonutrition use in surgical patients in Colombia.

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References

Meakins JL. Host defense mechanisms in surgical patients: effect of surgery and trauma. Acta Chir Scand Suppl. 1989;50: 43- 53.

Heys SD, Walker LG, Smith I, Eremin O. Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. Ann Surg. 1999;229(4): 467- 77.

Stableforth WD, Thomas S, Lewis SJ. A systematic review of the role of immunonutrition in patients undergoing surgery for head and neck cancer. Int J Oral Maxillofac Surg. 2009;38(2):103-10.

Zhang Y, Gu Y, Guo T, Li Y, Cai H. Perioperative immunonutrition for gastrointestinal cancer: a systematic review of randomized controlled trials. Surg Oncol. 2012;21(2):e87-95.

Senkal M, Zumtobel V, Bauer KH, Marpe B, Wolfram G, Frei A, et al. Outcome and Cost-effectiveness of Perioperative Enteral Immunonutrition in Patients Undergoing Elective Upper Gastrointestinal Tract Surgery. A Prospective Randomized Study. Arch Surg. 1999;134(12):1309-16.

Marik PE, Flemmer M. The immune response to surgery and trauma: Implications for treatment. J Trauma Acute Care Surg. 2012;73(4):801-808.

Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med.1991;325(8):525-32.

Heyland DK. Immunonutrition in the critically ill patient: putting the cart before the horse? Nutr Clin Pract. 2002;17(5):267-72.

Heyland DK, Novak F. Immunonutrition in the critically ill patient: more harm than good? JPEN J Parenter Enteral Nutr. 2001;25(2 Suppl):S51-56.

Koretz RL. Immunonutrition: fact, fantasy, and future. Curr Gastroenterol Rep. 2002;4(4):332-7.

McCowen KC, Bistrian BR. Immunonutrition: problematic or problem solving? Am J Clin Nutr. 2003;77(4):764-70.

Bermudez C, Sanabria Á, Vega V. Soporte nutricional del paciente adulto. Resultados de la reunión de consenso de la Asociación Colombiana de Nutrición Clínica. Rev Colomb Cir. 2013;28(2):15.

Lin E, Calvano SE, Lowry SF. Cytokine response in abdominal surgery. En: Schein M, Wise L, eds. Cytokines and the Abdominal Surgeon. Austin: Landes,1998. p.17-34.

Uauy R. Academic-industry partnerships in addressing nutrition--[infection-immunity-inflammation] interactions. Br J Nutr. 2007;98 Suppl 1:S17-23.

Suchner U, Kuhn KS, Furst P. The scientific basis of immunonutrition. Proc Nutr Soc. 2000;59(4):553-63.

Kudsk KA. Immunonutrition in surgery and critical care. Annu Rev Nutr. 2006;26:463-79.

Zheng Y, Li F, Qi B, Luo B, Sun H, Liu S, et al. Application of perioperative immunonutrition for gastrointestinal surgery: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2007;16(Suppl)1:253-7.

Braga M, Gianotti L, Radaelli G, Vignali A, Mari G, Gentilini O, et al. Perioperative immunonutrition in patients undergoing cancer surgery: results of a randomized double-blind phase 3 trial. Arch Surg. 1999;134(4):428-33.

Cerantola Y, Hubner M, Grass F, Demartines N, Schäfer M. Immunonutrition in gastrointestinal surgery. Br J Surg. 2011;98(1):37-48.

de Luis DA, Izaola O, Aller R, Cuellar L, Terroba MC. A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Ann Nutr Metab. 2005;49(2):95-9.

Fujitani K, Tsujinaka T, Fujita J, Miyashiro I, Imamura H, Kimura Y, et al. Prospective randomized trial of preoperative enteral immunonutrition followed by elective total gastrectomy for gastric cancer. Br J Surg. 2012;99(5):621-9.

Gade J, Levring T, Hillingso J, Hansen CP, Andersen JR. The Effect of Preoperative Oral Immunonutrition on Complications and Length of Hospital Stay After Elective Surgery for Pancreatic Cancer--A Randomized Controlled Trial. Nutr Cancer. 2016;68(2):225-33.

Helminen H, Raitanen M, Kellosalo J. Immunonutrition in elective gastrointestinal surgery patients. Scand J Surg. 2007;96(1):46-50.

Ida S, Hiki N, Cho H, Sakamaki K, Ito S, Fujitani K, et al. Randomized clinical trial comparing standard diet with perioperative oral immunonutrition in total gastrectomy for gastric cancer. Br J Surg. 2017;104(4):377-83.

Luo Z, Wang J, Zhang Z, Li H, Huang L, Qiao Y, et al. Efficacy of Early Enteral Immunonutrition on Immune Function and Clinical Outcome for Postoperative Patients With Gastrointestinal Cancer. JPEN J Parenter Enteral Nutr. 2017:148607117715439.

Marano L, Porfidia R, Pezzella M, Grassia M, Petrillo M, Esposito G, et al. Clinical and immunological impact of early postoperative enteral immunonutrition after total gastrectomy in gastric cancer patients: a prospective randomized study. Ann Surg Oncol. 2013;20(12):3912-3918.

Moskovitz DN, Kim YI. Does perioperative immunonutrition reduce postoperative complications in patients with gastrointestinal cancer undergoing operations? Nutr Rev. 2004;62(11):443-7.

Mudge L, Isenring E, Jamieson GG. Immunonutrition in patients undergoing esophageal cancer resection. Dis Esophagus. 2011;24(3):160-5.

Hegazi R, Hustead D, Evans D. Preoperative Standard Oral Nutrition Supplements vs Immunonutrition: Results of a Systematic Review and Meta Analysis. Am Coll Surg. Vol. 219, No. 5, November 2014.

Sodergren MH, Jethwa P, Kumar S, Duncan HD, Johns T, Pearce CB. Immunonutrition in patients undergoing major upper gastrointestinal surgery: a prospective double-blind randomised controlled study. Scand J Surg. 2010;99(3):153-161.

Song GM, Liu XL, Bian W, Wu J, Deng YH, Zhang H, et al. Systematic review with network meta-analysis: comparative efficacy of different enteral immunonutrition formulas in patients underwent gastrectomy. Oncotarget. 2017;8(14):23376-8.

Song GM, Tian X, Liang H, Yi LJ, Zhou JG, Zeng Z, et al. Role of Enteral Immunonutrition in Patients Undergoing Surgery for Gastric Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(31):e1311.

Song GM, Tian X, Zhang L,Ou YX, Yi LJ, Shuai T, et al. Immunonutrition Support for Patients Undergoing Surgery for Gastrointestinal Malignancy: Preoperative, Postoperative, or Perioperative? A Bayesian Network Meta-Analysis of Randomized Controlled Trials. Medicine (Baltimore). 2015;94(29):e1225.

Wong CS, Aly EH. The effects of enteral immunonutrition in upper gastrointestinal surgery: A systematic review and meta-analysis. Int J Surg. 2016;29:137-50.

Xu J, Zhong Y, Jing D, Wu Z. Preoperative enteral immunonutrition improves postoperative outcome in patients with gastrointestinal cancer. World J Surg. 2006;30(7):1284-9.

Yildiz SY, Yazicioglu MB, Tiryaki C, Ciftci A, Boyacioglu Z. The effect of enteral immunonutrition in upper gastrointestinalsurgery for cancer: a prospective study. Turk J Med Sci. 2016;46(2):393-400.

Falewee MN, Schilf A, Boufflers E, Cartier C, Bachmann P, Pressoir M, et al. Reduced infections with perioperative immunonutrition in head and neck cancer: exploratory results of a multicenter, prospective, randomized, double-blind study. Clin Nutr. 2014;33(5):776-84.

Machon C, Thezenas S, Dupuy AM, Assenat E, Michel F, Mas E, et al. Immunonutrition before and during radiochemotherapy: improvement of inflammatory parameters in head and neck cancer patients. Supportive Care Cancer. 2012;20(12):3129-35.

Riso S, Aluffi P, Brugnani M, Farinetti F, Pia F, D’Andrea F. Postoperative enteral immunonutrition in head and neck cancer patients. Clin Nutr. 2000;19(6):407-12.

Sorensen D, McCarthy M, Baumgartner B, Demars S. Perioperative immunonutrition in head and neck cancer. Laryngoscope. 2009;119(7):1358-64.

Turnock A, Calder PC, West AL, Izzard M, Morton RP, Plank LD. Perioperative immunonutrition in well-nourished patients undergoing surgery for head and neck cancer: evaluation of inflammatory and immunologic outcomes. Nutrients. 2013;5(4):1186-99.

Vasson MP, Talvas J, Perche O, Dillies AF, Bachmann P, Pezet D, et al. Immunonutrition improves functional capacities in head and neck and esophageal cancer patients undergoing radiochemotherapy: a randomized clinical trial. Clin Nutr.. 2014;33(2):204-10.

Farreras N, Artigas V, Cardona D, Rius X, Trias M, Gonzalez JA. Effect of early postoperative enteral immunonutrition on wound healing in patients undergoing surgery for gastric cancer. Clin Nutr. 2005;24(1):55-65.

Kamocki Z, Matowicka-Karna J, Gryko M, Zareba K, Kedra B, Kemona H. The effect of perioperative immunonutrition on the phagocytic activity of blood platelets in advanced gastric cancer patients. Clin Dev Immunol. 2013;2013:435672.

Klek S, Szybinski P, Szczepanek K. Perioperative immunonutrition in surgical cancer patients: a summary of a decade of research. World J Surg. 2014;38(4):803-12.

Mabvuure NT, Roman A, Khan OA. Enteral immunonutrition versus standard enteral nutrition for patients undergoing oesophagogastric resection for cancer. Int J Surg. 2013;11(2):122-7.

Qiang H, Hang L, Shui SY. The curative effect of early use of enteral immunonutrition in postoperative gastric cancer: a meta-analysis. Minerva Gastroenterol Dietol. 2017;63(3):285-92.

Bastian L, Weimann A. Immunonutrition in patients after multiple trauma. Br J Nutr. 2002;87(Suppl 1): S133-134.

Beale RJ, Bryg DJ, Bihari DJ. Immunonutrition in the critically ill: a systematic review of clinical outcome. Crit Care Med. 1999;27(12):2799-805.

Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr. 2007;98(Suppl 1):S133-9.

Chuntrasakul C, Siltham S, Sarasombath S, Sittapairochana C, Leowattana W, Chockvivatanavanit S, et al. Comparison of a immunonutrition formula enriched arginine, glutamine and omega-3 fatty acid, with a currently high-enriched enteral nutrition for trauma patients. J Med Assoc Thai. 2003;86(6):552-61.

Li SL, Xu YH, Wang X, Liu XF, Zhao L. Effects of enteral immunonutrition on immune function in patients with multiple trauma. World J Emerg Med. 2011;2(3):206-9.

Lorenz KJ, Schallert R, Daniel V. Immunonutrition - the influence of early postoperative glutamine supplementation in enteral/parenteral nutrition on immune response, wound healing and length of hospital stay in multiple trauma patients and patients after extensive surgery. GMS Interdiscip Plast Reconstr Surg DGPW. 2015;4:Doc15.

Marik PE, Zaloga GP. Immunonutrition in critically ill patients: a systematic review and analysis of the literature. Intensive Care Med. 2008;34(11):1980-90.

Alexander JW. Role of immunonutrition in reducing complications following organ transplantation. Transplant Proc. 2000;32(3):574-5.

Alexander JW. Immunonutrition in kidney and liver transplant recipients. Exp Clin Transplant. 2014;12(Suppl 1):34-37.

Bharadwaj S, Rivas JM, Jevenn A, Hanouneh I, Steiger E. Immunonutrition in patients undergoing liver transplantation: Too premature to draw conclusions. Hepatology. 2016;63(5):1741-2.

Kota H, Chamberlain RS. Immunonutrition Is Associated With a Decreased Incidence of Graft-Versus-Host Disease in Bone Marrow Transplant Recipients: A Meta-Analysis. JPEN J Parenter Enteral Nutr. 2017;41(8):1286-92.

Lei Q, Wang X, Zheng H, Bi J, Tan S, Li N. Peri-operative immunonutrition in patients undergoing liver transplantation: a meta-analysis of randomized controlled trials. Asia Pac J Clin Nutr. 2015;24(4):583-90.

Nagata S, Shirabe K, Sugimachi K, Ikegami T, Yoshizumi T, Uchiyama H, et al. Pilot study of preoperative immunonutrition with antioxidants in living donor liver transplantation donors. Fukuoka Igaku Zasshi. 2013;104(12):530-8.

Nickkholgh A, Schneider H, Encke J, Buchler MW, Schmidt J, Schemmer P. PROUD: Effects of preoperative long-term immunonutrition in patients listed for liver transplantation. Trials. 2007;8:20.

Plank LD, Mathur S, Gane EJ, Peng SL, Gillanders LK, Mcllroy K, et al. Perioperative immunonutrition in patients undergoing liver transplantation: a randomized double-blind trial. Hepatology. 2015;61(2):639-47.

Plank LD, McCall JL, Gane EJ, Rafique M, Gillanders LK, Mcllroy K, et al. Pre- and postoperative immunonutrition in patients undergoing liver transplantation: a pilot study of safety and efficacy. Clin Nutr. 2005;24(2):288-96.

Bertolini G, Iapichino G, Radrizzani D, Facchini R, Simini B, Bruzzone P, et al. Early enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial. Intensive Care Med. 2003;29(5):834-40.

Briassoulis G, Filippou O, Hatzi E, Papassotiriou I, Hatzis T. Early enteral administration of immunonutrition in critically ill children: results of a blinded randomized controlled clinical trial. Nutrition. 2005;21(7-8):799-807.

Heyland DK, Samis A. Does immunonutrition in patients with sepsis do more harm than good? Intensive Care Med. 2003;29(5):669-71.

Knight DJW. Immunonutrition: increased mortality is associated with immunonutrition in sepsis. BMJ. 2003;327(7416):682-683.

Alivizatos V, Athanasopoulos P, Makris N, Karageorgos N. Early postoperative glutamine-supplemented parenteral nutrition versus enteral immunonutrition in cancer patients undergoing major gastrointestinal surgery. J BUON. 2005;10(1):119-22.

Atkinson S, Sieffert E, Bihari D. A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill. Guy’s Hospital Intensive Care Group. Crit Care Med. 1998;26(7):1164-72.

Bharadwaj S, Trivax B, Tandon P, Alkam B, Hanouneh I, Steiger E. Should perioperative immunonutrition for elective surgery be the current standard of care? Gastroenterol Rep (Oxf). 2016;4(2):87-95.

Radrizzani D, Bertolini G, Facchini R, Simini B, Bruzzone P, Zanforlin G, et al. Early enteral immunonutrition vs. parenteral nutrition in critically ill patients without severe sepsis: a randomized clinical trial. Intensive Care Med. 2006;32(8):1191-8.

Banerjee S, Garrison LP, Danel A, Ochoa Gautier JB, Flum DR. Effects of arginine-based immunonutrition on inpatient total costs and hospitalization outcomes for patients undergoing colorectal surgery. Nutrition. 2017;42:106-13.

Braga M, Gianotti L. Preoperative immunonutrition: cost-benefit analysis. JPEN J Parenter Enteral Nutr. 2005;29(1 Suppl):S57-61.

Gianotti L, Braga M, Frei A, Greiner R, Di Carlo V. Health care resources consumed to treat postoperative infections: cost saving by perioperative immunonutrition. Shock. 2000;14(3):325-30.

dos Reis AM, Kabke GB, Fruchtenicht AVG, Barreiro TD, Moreira LF. Cost-Effectiveness of Perioperative Immunonutrition in Gastrointestinal Oncologic Surgery: A Systematic Review. Arq Bras Cir Dig. 2016;29(2):121-5.

Senkal M, Mumme A, Eickhoff U, Geier B, Späth G, Wulfert D, et al. Early postoperative enteral immunonutrition: clinical outcome and cost-comparison analysis in surgical patients. Crit Care Med. 1997;25(9):1489-96.

Zhiping Y, Qiong W, Yunfang L, Daiming F. Effect of Perioperative Probiotics and Synbiotics on Postoperative Infections After Gastrointestinal Surgery: A Systematic Review With Meta-Analysis. JPEN. 2017;41(6):1051–1062.