Influencia de nutrientes y enfermedades metabólicas sobre la memoria: revisión de alcance
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https://doi.org/10.35454/rncm.v8n1.666Palabras clave:
Deficiencia cognitiva, memoria, función cognitiva, nutrimentos, enfermedades metabólicasResumen
Introducción: la preservación de la memoria y el estado cognitivo han sido estudiados con interés en los últimos años, buscando las razones por las que se ve disminuido (las enfermedades metabólicas) o las estrategias para mejorarla o detener su deterioro (los nutrimentos). Objetivo: examinar los estudios que asocian los nutrimentos y las enfermedades metabólicas a la memoria y la función cognitiva mediante una revisión de alcance. Métodos: se realizó una búsqueda exhaustiva en bases de datos incluyendo estudios clínicos y observacionales (únicamente para las enfermedades metabólicas). Los criterios de inclusión fueron estudios publicados desde 2018 (con un máximo de inicio de intervención de 2017), hasta 2024. Se excluyeron estudios que no especificaron características de población, tamaño de población, dosis de intervención y métodos utilizados para evaluar la función cognitiva. Resultados: se incluyeron 45 estudios, dentro de los que se encontró una mayor influencia positiva en micronutrientes como Vitaminas A, B9 y B12, y de minerales como el magnesio. Además, en estudios observacionales, se demostró asociación positiva entre las enfermedades metabólicas y el deterioro cognitivo. Conclusiones: las limitaciones de la cantidad y calidad de algunos estudios asociados con vitaminas y minerales, no permiten concluir el efecto positivo en el deterioro cognitivo, a diferencia de las enfermedades metabólicas que si tienen un efecto negativo.
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Cousins JN, Fernández G. The impact of sleep deprivation on declarative memory. Prog Brain Res. 2019: 27–53. doi: 10.1016/bs.pbr.2019.01.007
Zhang J, Yetton B, Whitehurst LN, Naji M, Mednick SC. The effect of zolpidem on memory consolidation over a night of sleep. Sleep. 2020; 43 (11): zsaa084. doi: 10.1093/sleep/zsaa084
Jia J, Hu J, Huo X, Miao R, Zhang Y, Ma F. Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer’s disease: a randomised, double-blind, placebo-controlled trial. J Neurol Neurosurg Psychiatry. 2019; 90 (12): 1347-52. doi: 10.1136/jnnp-2018-320199
Ma F, Zhou X, Li Q, Zhao J, Song A, An P, et al. Effects of folic acid and vitamin b12, alone and in combination on cognitive function and inflammatory factors in the elderly with mild cognitive impairment: a single-blind experimental design. Curr Alzheimer Res. 2019; 16 (7): 622-32. doi: 10.2174/1567205016666190725144629
Montero-Odasso M, Zou G, Speechley M, Almeida QJ, Liu-Ambrose T, Middleton LE, et al. Effects of exercise alone or combined with cognitive training and vitamin d supplementation to improve cognition in adults with mild cognitive impairment. JAMA Netw Open. 2023; 6 (7): e2324465. doi: 10.1001/jamanetworkopen.2023.24465
Zhou L, Bai X, Huang J, Tan Y, Yang Q. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment. Nutr Hosp. 2023; 40 (4): 724-3. doi: 10.20960/nh.04394
Fadó R, Molins A, Rojas R, Casals N. Feeding the Brain: Effect of nutrients on cognition, synaptic function, and AMPA receptors. Nutrients. 2022; 14 (19): 4137. doi: 10.3390/nu14194137. PMID: 36235789; PMCID: PMC9572450.
World Health Organization (WHO). Obesity and Overweight. [Internet]. 2025 [citado 3 de julio de 2024]. Disponible en: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
Singh-Manoux A, Dugravot A, Shipley M, Brunner EJ,
Elbaz A, Sabia S, Kivimaki M. Obesity trajectories and risk of dementia: 28 years of follow-up in the whitehall II Study. Alzheimer’s dement. 2018; 14 (2): 178–86. doi: 10.1016/j.jalz.2017.06.2637
Coppin G, Nolan-Poupart S, Jones-Gotman M, Small DM. Working memory and reward association learning impairments in obesity. Neuropsychologia. 2014; 65: 146–155. doi: 10.1016/j.neuropsychologia.2014.10.004
Vilarnau C, Stracker DM, Funtikov A, da Silva R, Estruch R, Bach-Faig A. Worldwide adherence to mediterranean diet between 1960 and 2011. Eur J Clin Nutr. 2019; 72:83–91. doi: 10.1038/s41430-018-0313-9
Ramey MM, Shields GS, Yonelinas AP. Markers of a plant-based diet relate to memory and executive function in older adults. Nutr Neurosci. 2022; 25 (2): 276–85. doi: 10.1080/1028415X.2020.1751506
Almaguer-González JA, García-Ramirez HJ, Padilla-Mirazo M, González-Ferral M. La dieta de la Milpa. Modelo de alimentación mesoamericana biocompatible [Internet]. 2015 [citado el 14 de mayo de 2024]. Disponible en: https://www.gob.mx/cms/uploads/attachment/file/98453/La_Dieta_de_la_Milpa.pdf
Gutema BT, Levecke B, Sorrie MB, Megersa ND, Zewdie TH, Yesera GE, et al. Effectiveness of intermittent iron and high-dose vitamin A supplementation on cognitive development of school children in southern Ethiopia: a randomized placebo-controlled trial. Am J Clin Nutr. 2024; 119 (2): 470–84. doi: 10.1016/j.ajcnut.2023.11.005
Bassouni R, Soliman M, Hussein LA, Monir Z, Abd El-Meged AA. Development and evaluating the biopotency of ready to eat liver meat balls in fighting anaemia and vitamin A deficiency, improving selected nutritional biochemical indicators and promoting the cognitive function among mildly anaemic Egyptian children aged 3–9 years. Public Health Nutr. 2022; 25 (11): 3182–94. doi: 10.1017/S1368980022000970
Zhou L, Bai X, Huang J, Tan Y, Yang Q. Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment. Nutr Hosp. 2023; 40 (4): 724-31. doi: 10.20960/nh.04394
Domínguez-López I, Casas R, Chiva-Blanch G, Martínez-González MÁ, Fitó M, Ros E, et al. Serum vitamin B12 concentration is associated with improved memory in older individuals with higher adherence to the Mediterranean diet. Clin Nutr. 2023; 42 (12): 2562–8. doi: 10.1016/j.clnu.2023.10.025
Yang T, Wang H, Xiong Y, Chen C, Duan K, Jia J, et al. Vitamin D supplementation improves cognitive function through reducing oxidative stress regulated by telomere length in older adults with mild cognitive impairment: a 12-Month randomized controlled trial. J Alzheimers Dis. 2020; 78 (4): 1509–18. doi: 10.3233/JAD-200926
Gingoyon A, Borkhoff CM, Koroshegyi C, Mamak E, Birken CS, Maguire JL, et al. Chronic iron deficiency and cognitive function in early childhood. Pediatrics. 2022; 150 (6): e2021055926. doi: 10.1542/peds.2021-055926
Barnett AL, Wenger MJ, Yunus FM, Jalal C, DellaValle DM. The effect of iron-fortified lentils on blood and cognitive status among adolescent girls in Bangladesh. Nutrients. 2023; 15 (23): 5001. doi: 10.3390/nu15235001
Zhang C, Hu Q, Li S, Dai F, Qian W, Hewlings S, et al. A Magtein®, Magnesium L-Threonate, -based formula improves brain cognitive functions in healthy chinese adults. Nutrients. 2022; 14 (24): 5235. doi : 10.3390/nu14245235
Zhu X, Borenstein AR, Zheng Y, Zhang W, Seidner DL, Ness R, et al. Ca: Mg Ratio, APOE Cytosine modifications, and cognitive function: results from a randomized trial. J Alzheimers Dis. 2020; 75 (1): 85–98. doi: 10.3233/JAD-191223
de Vargas L da S, Jantsch J, Fontoura JR, Dorneles GP, Peres A, Guedes RP. Effects of zinc supplementation on inflammatory and cognitive parameters in middle-aged women with overweight or obesity. Nutrients. 2023; 15 (20): 4396. doi: 10.3390/nu15204396
Manippa V, Lupo R, Tommasi L, Brancucci A. Italian breakfast in mind: the effect of caffeine, carbohydrate and protein on physiological state, mood and cognitive performance. Physiol Behav. 2021; 234: 113371. doi: 10.1016/j.physbeh.2021.113371
Lin YS, Weibel J, Landolt HP, Santini F, Slawik H, Borgwardt S, et al. Brain activity during a working memory task after daily caffeine intake and caffeine withdrawal: a randomized double-blind placebo-controlled trial. Scientific Reports. 2023; 13 (1): 1002. doi: 10.1038/s41598-022-26808-5
Berg J, Cooper J, Salonikas C, Seyedsadjadi N, Grant R. Acute caffeine intake in humans reduces post exercise performance in learning and memory. Hum Psychopharmacol. 2021; 36 (3): e2775. doi: 10.1002/hup.2775
Ajjimaporn A, Noppongsakit P, Ramyarangsi P, Siripornpanich V, Chaunchaiyakul R. A low- dose of caffeine suppresses EEG alpha power and improves working memory in healthy University males. Physiol Behav. 2022; 256: 113955. doi: 10.1016/j.physbeh.2022.113955
Power R, Nolan JM, Prado-Cabrero A, Roche W, Coen R, Power T, et al. Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial. Clin Nutr. 2022; 41 (2): 405–14. doi: 10.1016/j.clnu.2021.12.004
Patan MJ, Kennedy DO, Husberg C, Hustvedt SO, Calder PC, Khan J, et al. Supplementation with oil rich in eicosapentaenoic acid, but not in docosahexaenoic acid, improves global cognitive function in healthy, young adults: results from randomized controlled trials. Am J Clin Nutr. 2021; 114 (3): 914–24. doi: 10.1093/ajcn/nqab174
Malik A, Ramadan A, Vemuri B, Siddiq W, Amangurbanova M, Ali A, et al. ω-3 Ethyl ester results in better cognitive function at 12 and 30 months than control in cognitively healthy subjects with coronary artery disease: a secondary analysis of a randomized clinical trial. Am J Clin Nutr. 2021; 113 (5): 1168–76. doi: 10.1093/ajcn/nqaa420
Jorde R, Kubiak J, Svartberg J, Fuskevåg OM, Figenschau Y, Martinaityte I, et al. Vitamin D supplementation has no effect on cognitive performance after four months in mid-aged and older subjects. J Neurol Sci. 2019; 396:165–71. doi: 10.1016/j.jns.2018.11.020
Pasricha SR, Hasan MI, Braat S, Larson LM, Tipu SMMU,
Hossain SJ, et al. Benefits and risks of iron interventions in infants in rural Bangladesh. N Engl J Med. 2021; 385(11): 982–95. doi: 10.1056/NEJMoa2034187
Wenger MJ, Murray-Kolb LE, Scott SP, Boy E, Haas JD. Modeling relationships between iron status, behavior, and brain electrophysiology: evidence from a randomized study involving a biofortified grain in Indian adolescents. BMC Public Health. 2022; 22(1):1299. doi: 10.1186/s12889-022-13612-z
Huenges-Wajer IMC, Dorhout-Mees SM, van den Bergh WM, Algra A, Visser‐Meily JMA, Rinkel GJE, et al. Effect of magnesium on cognition after aneurysmal subarachnoid haemorrhage in a randomized trial. Eur J Neurol. 2018; 25 (12): 1486–9. doi: 10.3233/JAD-191223
Zabelina DL, Silvia PJ. Percolating ideas: The effects of caffeine on creative thinking and problem solving. Consciousness Cogn. 2020; 79: 102899. doi: 10.1016/j.concog.2020.102899
Franceschini S, Lulli M, Bertoni S, Gori S, Angrilli A, Mancarella M, et al. Caffeine improves text reading and global perception. J Psychopharmacol. 2020; 34(3): 315–25. doi: 10.1177/0269881119878178
Benson S, Tiplady B, Scholey A. Attentional and working memory performance following alcohol and energy drink: a randomised, double-blind, placebo-controlled, factorial design laboratory study. PLoS ONE. 2019;14(1): e0209239. doi: 10.1371/journal.pone.0209239
Sueyasu T, Yasumoto K, Tokuda H, Kaneda Y, Obata H, Rogi T, et al. Effects of long-chain polyunsaturated fatty acids in combination with lutein and zeaxanthin on episodic memory in healthy older adults. Nutrients. 2023 ; 15 (13): 2825. doi: 10.3390/nu15132825
Maltais M, Lorrain D, Léveillé P, Viens I, Vachon A, Houeto A, et al. Long-chain Omega-3 fatty acids supplementation and cognitive performance throughout adulthood: a 6-month randomized controlled trial. Prostaglandins, leukotrienes and essential fatty acids. 2022; 178:102415. doi: 10.1016/j.plefa.2022.102415
Leckie RL, Lehman DE, Gianaros PJ, Erickson KI, Sereika SM, Kuan DCH, et al. The effects of omega-3 fatty acids on neuropsychological functioning and brain morphology in mid-life adults: a randomized clinical trial. Psychol Med. 2020; 50(14):2425–34. doi: 10.1017/S0033291719002617
Teisen MN, Vuholm S, Niclasen J, Aristizabal-Henao JJ, Stark KD, Geertsen SS, et al. Effects of oily fish intake on cognitive and socioemotional function in healthy 8–9-year-old children: the FiSK Junior randomized trial. Am J Clin Nutr. 2020; 112(1): 74–83. doi: 10.1093/ajcn/nqaa050
Moran C, Scotto di Palumbo A, Bramham J, Moran A, Rooney B, de Vito G, et al. Effects of a six-month multi-ingredient nutrition supplement intervention of omega-3 polyunsaturated fatty acids, vitamin d, resveratrol, and whey protein on cognitive function in older adults: a randomised, double-blind, controlled trial. J Prev Alzheimers Dis. 2018; 5(3): 1–9. doi: 10.14283/jpad.2018.11
Kuszewski JC, Howe PRC, Wong RHX. Evaluation of cognitive performance following fish-oil and curcumin supplementation in middle-aged and older adults with overweight or obesity. J Nutr. 2020; 150(12): 3190–9. doi: 10.1093/jn/nxaa299
Berisha H, Hattab R, Comi L, Giglione C, Migliaccio S, Magni P. Nutrition and lifestyle interventions in managing dyslipidemia and cardiometabolic risk. Nutrients. 2025; 23;17(5):776. doi: 10.3390/nu17050776
Minari TP, Tácito LHB, Yugar LBT, Ferreira-Melo SE, Manzano CF, Pires AC, et al. Nutritional strategies for the management of type 2 diabetes mellitus: a narrative review. Nutrients. 2023; 15(24): 5096. doi: 10.3390/nu15245096
Dominguez LJ, Barbagallo M, Muñoz-Garcia M, Godos J, Martinez-Gonzalez MA. Dietary patterns and cognitive decline: key features for prevention. Curr Pharm Des. 2019; 25(22): 2428-42. doi: 10.2174/1381612825666190722110458.
Aguilar-Navarro SG, Carbajal-Silva JC, Palacios-Hernández MI, Gutiérrez-Gutierrez LA, Ávila-Funes JA, Mimenza-Alvarado AJ. Asociación entre los niveles de vitamina B12 y el deterioro cognitivo en personas mayores. Gac Méd Méx. 2023; 159( 1 ): 32-37. doi: 10.24875/gmm.22000187.
Leiva-Ordóñez AM, Martínez-Sanguinetti MA, Petermann-Rocha F, Nazar G, Troncoso-Pantoja C, Lanuza F, et al . Association between low vitamin D levels and cognitive impairment in Chilean older adults: findings of the National Health Survey 2016-2017. Rev méd Chile. 2023; 151(4): 469-477. doi: 10.4067/s0034-98872023000400469
Pérez-Lizaur AB, Marván-Laborde L. Manual de dietas normales y terapéuticas. Los alimentos en la salud y la enfermedad. 5ª ed. México: Ediciones Porrúa; 2022.
Dominguez LJ, Veronese N, Vernuccio L, Catanese G, Inzerillo F, Salemi G, Barbagallo M. Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia. Nutrients. 2021; 13(11): 4080. doi: 10.3390/nu13114080
Jacobs DR; Orlich MJ. Diet pattern and longevity: Do simple rules suffice? Am J Clin Nutr. 2014, 100 (Suppl. 1): 313S–9S. doi: 10.3945/ajcn.113.071340
Gil-Martínez V, Avedillo-Salas A, Santander-Ballestín S. Vitamin supplementation and dementia: a systematic review. Nutrients. 2022; 14(5): 1033. doi: 10.3390/nu14051033
Chaudhari K, Sumien N, O’Bryant SE, Johnson L, D’Agostino D, Edwards M, et al. Vitamin C supplementation, APOE4 genotype and cognitive functioning in a rural-dwelling cohort. J Nutr Health Aging. 2016; 20(8): 841–4.doi: 10.1007/s12603-016-0705-2
Lopresti AL, Smith SJ, Riggs ML, Major RA, Gibb TG, Wood SM, et al. An examination into the effects of a nutraceutical supplement on cognition, stress, eye health, and skin satisfaction in adults with self-reported cognitive complaints: a randomized, double-blind, placebo-controlled trial. Nutrients. 2024;16(11): 1770.doi: 10.3390/nu16111770
Jing-Hong L, Lin L, Jia-Yu L, Xin-Yuan Q, Jing L, Sheng Q, et al. Contributions of modifiable risk factors to dementia incidence: a bayesian network analysis. J Am Med Dir Assoc. 2020, 21(11): 1592–1599.e13. doi: 0.1016/j.jamda.2020.04.006
Selman A, Burns S, Reddy AP, Culberson J, Reddy PH. The role of obesity and diabetes in dementia. Int J Mol Sci. 2022; 23(16): 9267. doi: 10.3390/ijms23169267
Shi Y, Lin F, Li Y, Wang Y, Chen X, Meng F, et al. Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants. BMC Med. 2023; 21(1): 266. doi: 10.1186/s12916-023-02940-5.
Hossain-Khan SH, Hegde V. Obesity and diabetes mediated chronic inflammation: a potential biomarker in Alzheimer’s disease. J Pers Med. 2020; 10(2): 42. doi: 10.3390/jpm10020042.
Kopp, W. How western diet and lifestyle drive the pandemic of obesity and civilization diseases. Diabetes Metab Syndr Obes. 2019; 12: 2221-36. doi: 10.2147/DMSO.S216791.
Šuput-Omladič J, Slana-Ozimič A, Vovk A, Šuput D, Repovš G, Dovc K, et al. Acute hyperglycemia, and spatial working memory in adolescents with type 1 diabetes. Diabetes Care. 2020; 43(8):1941–4. doi: 10.2337/dc20-0171
Backeström A, Papadopoulos K, Eriksson S, Olsson T, Andersson M, Blennow K, et al. Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes. PLoS ONE. 2021; 16(3): e0247753. doi: 10.1371/journal.pone.0247753
Nagar SD, Pemu P, Qian J, Boerwinkle E, Cicek M, Clark CR, et al. Investigation of hypertension and type 2 diabetes as risk factors for dementia in the All of us cohort. Sci Rep. 2022; 12(1):19797. doi: 10.1038/s41598-022-23353-z
Thomassen JQ, Tolstrup JS, Benn M, Frikke-Schmidt R. Type-2 diabetes and risk of dementia: observational and Mendelian randomisation studies in 1 million individuals. Epidemiology and Psychiatric Sciences. 2020; 29: e118. doi: 10.1017/S2045796020000347
Young-Gun K, Dong-Gyu P, So-Young M, Ja-Young J, Hae-Jin K, Dae-Jung K, et al. Hypoglycemia and dementia risk in older patients with type 2 diabetes mellitus: a propensity-score matched analysis of a population-based cohort study. Diabetes Metab J. 2020; 44(1):125-33. doi: 10.4093/dmj.2018.0260
Morys F, Dadar M, Dagher A. Association between midlife obesity and its metabolic consequences, cerebrovascular disease, and cognitive decline. J Clin Endocrinol Metab. 2021; 106(10): e4260–74. doi: 10.1210/clinem/dgab135
Nordestgaard LT, Christoffersen M, Afzal S, Nordestgaard BG, Tybjærg-Hansen A, Frikke-Schmidt R. Triglycerides as a shared risk factor between dementia and atherosclerotic cardiovascular disease: a study of 125 727 individuals. Clin Chem. 2021; 67(1): 245–55. doi: 10.1093/clinchem/hvaa269
den Brok MGHE, Eggink E, Hoevenaar-Blom MP, van Gool WA, Moll van Charante EP, Richard E, et al. Low values for blood pressure, BMI, and Non-HDL cholesterol and the risk of late-life dementia. Neurology. 2022; 99(15): e1630-39. doi: 10.1212/WNL.0000000000200954
Arrieta-Antón E, Baz-Rodríguez PG. Estudio DECOG: deterioro cognitivo en el paciente con riesgo cardiovascular. SEMERGEN. 2021; 47(3): 174–80. doi: 10.1016/j.semerg.2021.01.009
Morys F, Potvin O, Zeighami Y, Vogel J, Lamontagne-Caron R, Duchesne S, et al. Obesity-associated neurodegeneration pattern mimics Alzheimer’s disease in an observational cohort study. J Alzheimers Dis. 2023; 91(3): 1059–71. doi: 10.3233/JAD-220535
Dekkers IA, Jansen PR, Lamb HJ. Obesity, brain volume, and white matter microstructure at mri: a cross-sectional UK Biobank Study. Radiology. 2019; 291(3): 763–71. doi: 10.1148/radiol.2019181012
Hou Q, Guan Y, Yu W, Liu X, Wu L, Xiao M, et al. Associations between obesity and cognitive impairment in the Chinese elderly: an observational study. Clin Interv Aging. 2019; 14: 367–73. doi: 10.2147/CIA.S192050
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Derechos de autor 2025 Fernando Emmanuel Garcini Enriquez, Claudia Nelly Orozco González

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