Sarcopenia in patients with chronic heart failure
DOI:
https://doi.org/10.35454/rncm.v8n1.662Keywords:
Heart failure, Malnutrition, Sarcopenia, Aged, ArgentinaAbstract
Introduction: Chronic Heart Failure (CHF) induces a catabolic state that can generate sarcopenia, which is prevalent in 55,0 % of hospitalized patients. Objective: determine the frequency of risk of sarcopenia (RS) and probable sarcopenia (PS) in patients with CHF upon hospital admission and the agreement between both tools. Likewise, describe its relationship with characteristics of the population. Methods: observational and analytical study in patients over 18 years of age with CHF hospitalized from November 2022 to June 2023. SR variables were analyzed according to the SARC-F and SP tool using manual dynamometry. The Fisher and Mann-Whitney U tests analyzed the association between variables. The Kappa test evaluated the concordance between the tools, while sensitivity and specificity measured the predictive capacity. Results: 81.00% (95% CI 73.31-88.69) presented RS and 85.00% (95% CI 81.63-94.37) SP. The RS was associated with the presence of hospitalization (p= 0.014) and number of hospitalizations (p= 0.016). Anorexia was associated with the results of both tools (p= 0.004; p= 0.01). Nutritional status was related to SP (p= 0.049). Moderate agreement of 84.00% was found between SARC-F and manual dynamometry (Kappa= 0.4346, p < 0.001). The SARC-F showed fair predictive capacity. Conclusions: most of the sample presented a risk and probability of sarcopenia, with moderate concordance between the tools.
Downloads
References
Sociedad Argentina de Cardiología. Consenso de Insuficiencia Cardíaca. Rev Argent Cardiol. 2023; 91(2):1-80. doi: 10.7775/rac.es.v91.s2.
Rico-de la Rosa L, Robledo-Valdez M, Cervantes-Pérez E, Cervantes-Guevara G, Cervantes-Cardona GA, Ramírez-Ochoa S, et al. Implicaciones médicas y nutricionales en insuficiencia cardiaca crónica: fortalezas y limitaciones. Arch Cardiol Mex. 2021; 91(2): 221-8. doi: 10.24875/acm.20000260.
Zugasti-Murillo A, Breton-Lesmes I, Ballesteros-Pomar MD, Botella-Romero FB. Valoración de desnutrición relacionada con la enfermedad (DRE) y de sarcopenia en el paciente con insuficiencia cardíaca (IC). Secardiologia.es [Internet]. 2022 [citado el 16 de julio de 2024]. Disponible en: https://secardiologia.es/images/publicaciones/documentos-consenso/valoracion-de-desnutricion-relacionada-con-la-enfermedad-dre-y-de-sarcopenia-en-el-paciente-con-insuficiencia-cardiaca.pdf.
Kirsch R, Matthews K, Williams V. Using global criteria to detect malnutrition: Application in disease states. Nutr Clin Pract. 2020; 35(1): 85–97.doi: 10.1002/ncp.10444.
Hirose S, Matsue Y, Kamiya K, Kagiyama N, Hiki M, Dotare T, et al. Prevalence and prognostic implications of malnutrition as defined by GLIM criteria in elderly patients with heart failure. Clin Nutr. 2021; 40(6): 4334-40. doi:10.1016/j.clnu.2021.01.014.
Zhang Y, Zhang J, Ni W, Yuan X, Zhang H, Li P, et al. Sarcopenia in heart failure: a systematic review and meta-analysis. ESC Heart Fail. 2021; 8(2): 1007–17. doi: 10.1002/ehf2.13255
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age and ageing. 2019; 48(1): 16-31. doi: 10.1093/ageing/afy169.
Takumi N, Kentaro K, Nobuaki H, Kohei N, Takafumi I, Masashi Y, et al. SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment. Exp Gerontol. 2023; 171: 112021. doi: 10.1016/j.exger.2022.112021.
Laukkanen JA, Khan H, Lavie CJ, Voutilainen A, Kurl S, Young-Jae S, et al. Inverse Association of Handgrip Strength With Risk of Heart Failure. Mayo Clin Proc. 2021; 96(6): 1490-9. doi: 10.1016/j.mayocp.2020.09.040.
Dai KZ, Laber EB, Chen H, Mentz R, Malhotra C. Hand Grip Strength Predicts Mortality and quality of life in heart failure: insights from the Singapore cohort of patients with advanced heart failure. J Card Fail. 2023; 29(6): 911-8. doi: 10.1016/j.cardfail.2022.11.009.
Artham SM, Ventura HO. Insuficiencia cardíaca y la «paradoja de la obesidad»: la historia continúa. Rev Esp Cardiol. 2007; 60(11): 1113-17. doi: 10.1157/13111781
Gusmao-Sena MH, Curvello-Silva K, Barreto-Medeiros JM, Da-Cunha-Daltro CH. Association between sarcopenic obesity and cardiovascular risk: where are we?. Nutr Hosp. 2016; 33(5): 592. doi: 10.20960/nh.592.
Sciomer S, Moscucci F, Salvioni E, Marchese G, Bussotti M, Corrà U, et al. Role of gender, age and BMI in prognosis of heart failure. Eur J Prev Cardiol. 2020; 27(2): 46–51. doi: 10.1177/2047487320961980
Zapatero A, Barba R, Gonzalez N, Losa JE, Plaza S, Canora J, et al. Influencia de la obesidad y la desnutrición en la insuficiencia cardíaca aguda. Rev Esp Cardiol. 2012; 65(5): 421–6. doi: 10.1016/j.recesp.2011.09.011
Organización Mundial de la Salud. Informe Mundial sobre el Envejecimiento y la Salud [Internet]. 2015. [citado el 14 de julio del 2023]. Disponible en: https://apps.who.int/iris/bitstream/handle/10665/186471/WHO_FWC_ALC_15.01_sp a.pdf
de Ulíbarri JI, González-Madroño A, de Villar NGP, González P, González B, Mancha U, et al. CONUT: una herramienta para controlar el estado nutritivo. Primera validación en una población hospitalaria. Nutr Hosp. 2005; 20(1): 38–45. PMID: 15762418.
Sociedad Española de Geriatría y Gerontología. Valoración Nutricional del Anciano. Recomendaciones prácticas de los expertos en geriatría y nutrición. [Internet]. 2007. [citado el 14 de julio 2023]. Disponible en: https://www.segg.es/media/descargas/Acreditacion%20de%20Calidad%20SEGG/Residencias/valoracion_nutricional_anciano.pdf.
Tanaka S, Kamiya K, Hamazaki N, Matsuzawa R, Nozaki K, Maekawa E, et al. Utility of SARC-F for assessing physical function in elderly patients with cardiovascular disease. J Am Med Dir Assoc. 2017; 18(2): 176–81. doi: 10.1016/j.jamda.2016.10.019.
Murillo A, Bretón Lesmes I, Ballesteros Pomar MD, Botella Romero F. Desnutrición Relacionada con la Enfermedad y de Sarcopenia en el paciente con Insuficiencia Cardiaca. [Internet]. 2023 [citado el 14 Julio 2023]. Disponible: documento-valoración-desnutrición-insuficiencia (seen.es)
ManualsLib. Normative Grip Strength Data - Patterson medical Jamar smart user manual. [internet]. 2017 [citado el 16 de julio de 2024]. Disponible en: https://www.manualslib.com/manual/1272692/Patterson-Medical-Jamar-Smart.html?p age=10
Sousa-Santos A, Amaral TF. Differences in handgrip strength protocols to identify sarcopenia and frailty - a systematic review. BMC Geriatr. 2017; 17(1): 238. doi: 10.1186/s12877-017-0625-y
Hogre JY. Hand Grip strength measured by high precision dynamometry in healthy subjects from 5 to 80 years. BMC Musculoskelet Disord. 2015; 16: 139. doi: 10.1186/s12891-015-0612-4
Abraira V. El índice kappa. Semergen. 2001; 27(5): 247–9. doi: 10.1016/s1138-3593(01)73955-x
Power L, Mullally D, Gibney ER, Clarke M, Visser M, Volkert D, et al. A review of the validity of malnutrition screening tools used in older adults in community and healthcare settings - A MaNuEL study. Clin Nutr ESPEN. 2018; 24: 1-13. doi: 10.1016/j.clnesp.2018.02.00
Chandrashekhar LI, Vaishali K, Babu AS. Prevalence of sarcopenia in heart failure: a systematic review. Indian Heart J. 2023; 75(1): 36-42. doi: 10.1016/j.ihj.2022.12.004
Ramos-Ramírez KE, Soto A. Sarcopenia, mortalidad intrahospitalaria y estancia hospitalaria prolongada en adultos mayores internados en un hospital de referencia peruano. Acta Med Peru. 2020; 37(4): 447-54. doi: 10.35663/amp.2020.374.1071
Abdou M. Usefulness of upper and lower limb muscle strength in the evaluation of clinical severity of heart failure in elderly patients. World J Cardiovasc Dis. 2019; 09(05): 370–83. doi: 10.4236/wjcd.2019.95033
López-Azor JC. Inflamación e insuficiencia cardíaca: una relación compleja y bidireccional (parte I) [Internet]. 2020 (citado el 15 de julio del 2023). Disponible en: https://secardiologia.es/blog/11545-inflamacion-e-insuficiencia-cardiaca-una-relacion-compleja-y-bidireccional-parte-i.
Xu R, Chen XC, Wen FM, Xu H. Assessment of the relationship between sarcopenia and heart failure among postmenopausal women. Research Square. 2022; preprint (1): 1-11. DOI: https://doi.org/10.21203/rs.3.rs-2018737/v1
Kamisaka K, Kamiya K, Iwatsu K, Iritani N, Imoto S, Adachi T, et al. Impact of weight loss in patients with heart failure with preserved ejection fraction: results from the FLAGSHIP study. ESC Heart Fail. 2021; 8(6): 5293–303. doi: 10.1002/ehf2.13619
Tarraga-Lopez PJ. Análisis de la influencia del Índice de Masa Corporal en la evolución de la Insuficiencia Cardíaca en una zona de salud. Rev Esp Nutr Humana Diet. 2020; 24(2): 103–10.doi: 10.14306/renhyd.24.2.931
Fernández-Pombo A, Rodríguez-Carnero G, Castro AI, Cantón-Blanco A, Seoane LM, Casanueva FF, et al. Relevance of nutritional assessment and treatment to counteract cardiac cachexia and sarcopenia in chronic heart failure. Clin Nutr. 2021; 40(9): 5141–55. doi: 10.1016/j.clnu.2021.07.027
Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011; 40(4): 423–9. doi: 10.1093/ageing/afr051
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Maria Luisa Belén Rioja, Andrea Paola Greco, Pilar Navarro

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.