Aplicaciones clínicas del ayuno intermitente

Marisa Ester Canicoba

doi:10.35454/rncm.v3n2.174

Autores

Marisa Ester Canicoba Licenciada en Nutrición

DOI:

https://doi.org/10.35454/rncm.v3n2.174

Palavras-chave:

Jejum intermitente, Ritmo circadiano, Microbiota intestinal

Resumo

O objetivo desta revisão é fornecer uma visão geral do jejum intermitente, resumir as evidências e discutir os mecanismos fisiológicos pelos quais o jejum intermitente pode conduzir a um benefício para a saúde. Nas últimas décadas, várias linhas de evidências científicas apoiam a implementação desse tipo de jejum através dos benefícios na regulação metabólica dos efeitos no ritmo circadiano, no microbioma intestinal, na perda de peso, na diabetes mellitus, na esteatose hepática, na doença cardiovascular, entre outras patologias. No entanto, são necessários estudos randomizados para determinar se o jejum intermitente, como estilo de vida, é benéfico para a saúde.

Downloads

Não há dados estatísticos.

Referências

Phillips MCL. Fasting as a Therapy in Neurological Disease. Nutrients. 2019; 11(10):2501. Doi: 10.3390/nu11102501.

de Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med. 2019; 381(26):2541-51. doi: 10.1056/NEJMra1905136.

Puchalska P, Crawford PA. Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics. Cell Metab. 2017;25(2):262-84. doi: 10.1016/j.cmet.2016.12.022.

Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mainous AG, et al. Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting. Obesity. >2018; 26(2):254-68. doi: 10.1002/oby.22065.

Patterson RE, Sears DD. Metabolic Effects of Intermittent Fasting. Annu Rev Nutr. 2017;37:371-93. doi: 10.1146/annurev-nutr-071816-064634.

Bagherniya M, Butler AE, Barreto GE, Sahebkar A. The effect of fasting or calorie restriction on autophagy induction: a review of the literature. Ageing Res Rev. 2018;47:183-97. doi: 10.1016/j.arr.2018.08.004.

Potter GMD, Skene DJ, Arendt J, Cade JE, Grant PJ, Hardie LJ. Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures. Endocr Rev. 2016; 37(6):584-608. doi: 10.1210/er.2016-1083.

Gamble KL, Berry R, Frank SJ, Young ME. Circadian Clock Control of Endocrine Factors. Nat Rev Endocrinol.2014;10(8):466-75. Doi: 10.1038/nrendo.2014.78.

Gibbs M, Harrington D, Starkey S, Williams P, Hampton S. Diurnal postprandial responses to low and high glycaemic index mixed meals. Clin Nutr. 2014;33(5):889–94. doi: 10.1016/j.clnu.2013.09.018.

Potter GD, Cade JE, Grant PJ, Hardie LJ. Nutrition and the Circadian System. Br J Nutr. 2016;116(3):434-42. Doi: 10.1017/S0007114516002117.

Varady KA, Bhutani S, Klempel MC, Kroeger CM, Trepanowski JF, Haus JM, et al. Alternate Day Fasting for Weight Loss in Normal Weight and Overweight Subjects: A Randomized Controlled Trial. Nutr J. 2013; 12(1):146. doi: 10.1186/1475-2891-12-146.

Herieka M, Erridge C. High-fat Meal Induced Postprandial Inflammation. Mol Nutr Food Res. 2014; 58(1):136-46. doi: 10.1002/mnfr.201300104.

Laugerette F, Alligier M, Bastard JP, Drai J, Chanséaume E, Lambert-Porcheron S, et al. Overfeeding Increases Postprandial Endotoxemia in Men: Inflammatory Outcome May Depend on LPS Transporters LBP and sCD14. Mol Nutr Food Res. 2014;58(7):1513-8. doi: 10.1002/mnfr.201400044.

Furmli S, Elmasry R, Ramos M, Fung J. Therapeutic Use of Intermittent Fasting for People With Type 2 Diabetes as an Alternative to Insulin. BMJ Case Rep. 2018: bcr2017221854. doi: 10.1136/bcr-2017-221854.

Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even Without Weight Loss in Men With Prediabetes. Cell Metab. 2018; 27(6):1212-21.e3. doi: 10.1016/j.cmet.2018.04.010.

Harvie M, Howell A. Potential Benefits and Harms of Intermittent Energy Restriction and Intermittent Fasting Amongst Obese, Overweight and Normal Weight Subjects- A Narrative Review of Human and Animal Evidence. Behav Sci. 2017; 7(1); 4. doi: 10.3390 / bs7010004.

Harris L, Hamilton S, Azevedo LB, Olajide J, De Brún C, Waller G, et al. Intermittent fasting interventions for treatment of overweight and obesity in adults: A systematic Review and Meta-Analysis. JBI Database System Rev and Implement Rep. 2018;16(2):507–47. doi: 10.11124/JBISRIR-2016-003248.

Varady KA. Intermittent Versus Daily Calorie Restriction: Which Diet Regimen Is More Effective for Weight Loss? Obes Rev. 2011;12(7):e593-601. doi: 10.1111/j.1467-789X.2011.00873.x.

Trepanowski JF, Kroeger CM, Barnosky A, Klempel MC, Bhutani S, Hoddy KK, et al. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017; 177(7):930-8. doi: 10.1001/jamainternmed.2017.0936.

Ma X, Chen Q, Pu Y, Guo M, Jiang Z, Huang W, et al. Skipping Breakfast Is Associated With Overweight and Obesity: A Systematic Review and Meta-Analysis. Obes Res Clin Pract. 2020;14(1):1-8. Doi: https://doi.org/10.1016/j.orcp.2019.12.002.

Santos HO, Macedo RCO. Impact of Intermittent Fasting on the Lipid Profile: Assessment Associated With Diet and Weight Loss. Clin Nutr ESPEN. 2018; 24:14-21. doi: 10.1016/j.clnesp.2018.01.002.

Uzhova I, Fuster V, Fernández-Ortiz A, Ordovás JM, Sanz J, Fernández-Friera L, et al. The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study. J Am Coll Cardiol. 2017;70(15):1833-42. doi: 10.1016/j.jacc.2017.08.027.

de Groot S, Pijl H, van der Hoeven JJM, Kroep JR. Effects of Short-Term Fasting on Cancer Treatment. J Exp Clin Cancer Res. 2019;38(1):209. doi: 10.1186/s13046-019-1189-9.

Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, et al. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. 2015; 70(9):1097-104. doi: 10.1093/gerona/glv057.

Brandhorst S, Longo VD. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016;207:241-66. doi: 10.1007/978-3-319-42118-6_12.

Antunes F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, et al. Autophagy and intermittent fasting: the connection for cancer therapy? Clinics. 2018;73:e814s. doi: 10.6061/clinics/2018/e814s.

Kopeina GS, Senichkin VV, Zhivotovsky B. Caloric Restriction - A Promising Anti-Cancer Approach: From Molecular Mechanisms to Clinical Trials. Biochim Biophys Acta Rev Cancer. 2017;1867(1):29-41. doi: 10.1016/j.bbcan.2016.11.002.

Nencioni A, Caffa I, Cortellino S, Longo VD. Fasting and Cancer: Molecular Mechanisms and Clinical Application. Nat Rev Cancer. 2018; 18(11):707-19. doi: 10.1038/s41568-018-0061-0.

Elsakka AMA, Bary MA, Abdelzaher E, Elnaggar M, Kalamian M, Mukherjee P, et al. Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up. Front Nutr. 2018;5:20. doi: 10.3389 / fnut.2018.00020.

Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent Metabolic Switching, Neuroplasticity and Brain Health. Nat Rev Neurosci. 2018; 19(2):63-80. doi: 10.1038/nrn.2017.156.

Fann DYW, Ng GYQ, Poh L, Arumugam TV. Positive effects of intermittent fasting in ischemic stroke. Exp Gerontol. 2017;89:93–102. doi: 0.1016/j.exger.2017.01.014.

Martin K, Jackson CF, Levy RG, Cooper PN. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2016;2: CD001903. doi: 10.1002 / 14651858.CD001903.pub3.

Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, et al. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016;15(10):2136-46. doi: 10.1016/j.celrep.2016.05.009.

Fitzgerald KC, Vizthum D, Henry-Barron B, Schweitzer A, Cassard SD, Kossoff E, et al. Effect of Intermittent vs. Daily Calorie Restriction on Changes in Weight and Patient-Reported Outcomes in People With Multiple Sclerosis. Mult Scler Relat Disord. 2018;23:33-9. doi: 10.1016/j.msard.2018.05.002.

Carpaij OA, van den Berge M. The Asthma-Obesity Relationship: Underlying Mechanisms and Treatment Implications. Curr Opin Pulm Med. 2018;24(1):42-9. doi: 10.1097/MCP.0000000000000446.

Mohan A, Grace J, Wang BR, Lugogo N. The Effects of Obesity in Asthma. Curr Allergy Asthma Rep. 2019; 19(10):49. doi: 10.1007 / s11882-019-0877-z.

Peters U, Dixon AE, Forno E. Obesity and Asthma. J Allergy Clin Immunol. 2018;141(4):1169-78. Doi: 10.1007/s11882-019-0877-z.

Badsha H. Role of Diet in Influencing Rheumatoid Arthritis Disease Activity. Open Rheumatol J. 2018;12:19–28. doi: 10.2174/1874312901812010019.

Longo VD, Mattson MP. Fasting: Molecular mechanisms and clinical applications. Cell Metab. 2014;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008.