Vitamina D na admissão e gravidade da doença em pacientes com COVID-19 na Unidade de Cuidados Intensivos

Autores

  • Victoria Carolina Gonzalez Sanatorio Allende
  • Cayetano Galletti Sanatorio Allende
  • Romina Alvarez Vizzoni Sanatorio Allende
  • Yanina Saldivar Sanatorio Allende
  • Nicolás Kessler Sanatorio Allende
  • Francisco Irades Sanatorio Allende
  • Estefanía Minoldo Sanatorio Allende
  • Pablo Calcagno Sanatorio Allende
  • Antonella Aliscioni Sanatorio Allende
  • Ursula Zaya Sanatorio Allende

DOI:

https://doi.org/10.35454/rncm.v6n2.485

Palavras-chave:

doença coronavirus 2019, vitamina D, ventilação mecânica, unidade de terapia intensiva

Resumo

Introdução: a 25-hidroxivitamina D (25(OH)D) reduziria a incidência de infecções respiratórias virais, devido ao seu efeito pleiotrópico na imunomodulação. 

Objetivo: investigar a possível associação entre a deficiência grave de 25(OH)D na admissão na unidade de terapia intensiva (UTI) e a gravidade da doença em pacientes com diagnóstico de COVID-19. Determinar se existe uma associação entre deficiência grave de 25(OH)D na admissão, necessidade de ventilação mecânica invasiva, comorbidades e mortalidade. 

Métodos: estudo observacional retrospectivo, que incluiu 164 pacientes com diagnóstico de COVID-19 internados na unidade de terapia intensiva que tiveram níveis plasmáticos de 25(OH)D nas primeiras 72 horas de internação. 

Resultados: 136 (83%) pacientes apresentaram deficiência de 25(OH)D (<30 ng/mL) e 35 (21%) tiveram 25(OH)D ≤12 ng/m. Pacientes com deficiência grave de 25(OH)D tiveram probabilidade significativamente maior de COVID-19 grave (OR 2,2, IC 95% 1,02 a 5,06, p= 0,049) e apresentaram maior probabilidade de necessitar ventilação mecânica invasiva (OR 2,4, IC 95% 1,09 a 5,58, p=0,036). A mortalidade foi significativamente maior no grupo com deficiência grave de 25(OH)D (40% vs 22%, p=0,03), com OR 2,4, 95% IC 1,07 a 5,32, p=0,031. No modelo multivariado,a história de doença cardiovascular, deficiência grave de 25(OH)D, PaO2/FiO2 e ventilação mecânica invasiva permaneceram significativos. 

Conclusão: este estudo confirma que a deficiência grave de vitamina D está associada a uma afetação pulmonar mais grave, aumento da gravidade da doença e risco de morte em pacientes com COVID-19.

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Biografia do Autor

Victoria Carolina Gonzalez, Sanatorio Allende

Cayetano Galletti, Sanatorio Allende

Romina Alvarez Vizzoni, Sanatorio Allende

Yanina Saldivar, Sanatorio Allende

Nicolás Kessler, Sanatorio Allende

Francisco Irades, Sanatorio Allende

Estefanía Minoldo, Sanatorio Allende

Pablo Calcagno, Sanatorio Allende

Antonella Aliscioni, Sanatorio Allende

Ursula Zaya, Sanatorio Allende

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Publicado

2023-05-24

Como Citar

Gonzalez, V. C., Galletti, C., Alvarez Vizzoni, R. ., Saldivar, Y., Kessler, N., Irades, F., Minoldo, E. ., Calcagno, P., Aliscioni, A. ., & Zaya, U. (2023). Vitamina D na admissão e gravidade da doença em pacientes com COVID-19 na Unidade de Cuidados Intensivos. Jornal De Nutrição Clínica E Metabolismo, 6(2), 72–79. https://doi.org/10.35454/rncm.v6n2.485