Alterations in the sense of smell and taste in patients with chronic renal disease, transplant and dialysis and their association with nutritional status

Authors

  • Alba N. Carrillo-Degollado Colegio Mexiquense Universitario
  • Estefanía P. Salazar-Guzmán Colegio Mexiquense Universitario
  • Laura E. Gutierrez-Pliego Universidad del Noreste
  • Claudia N. Orozco-González Universidad Internacional Iberoamericana

DOI:

https://doi.org/10.35454/rncm.v6n3.500

Keywords:

Renal, Sense of smell, Dialysis, Sense of taste, Nutritional status

Abstract

Introduction: Chronic renal failure presents with alterations such as anosmia and dysgeusia caused by increased levels of uremic toxins. These can influence patient diet and nutritional status. 

Objective: To analyze the evidence found in the literature on the prevalence, pathophysiology and treatment of loss of taste and smell in patients with renal disease, any replacement therapy and renal transplant, and its association with nutritional status. 

Material and methods: This work is a narrative review. A search was made in PubMed, SciELO, Google Scholar, Elsevier, OVID, Medline and Scopus with the aim of determining the association between nutritional status and total or partial loss of smell and taste. 

Results: The relationship between the loss of smell and the degree of renal failure and accumulation of uremic toxins has been shown. A decreased sense of taste due to zinc deficit and urea elimination through saliva has been described. Altered taste perception in these hemodialysis patients is independently associated with high micronutrient deficits associated with nutritional status and higher mortality.

Conclusions: Loss of smell, taste or both is a frequent condition in patients with chronic renal failure and contributes to nutritional risk in these patients. 

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References

Robles-Osorio ML, Corona R, Morales T, Sabath E. Enfermedad renal crónica y olfato. Nefrología. 2020;40(2):120–5. doi: 10.1016/j.nefro.2019.04.009

Nigwekar SU, Zhao S, Wenger J, Hymes JL, Maddux FW, Thadhani RI, et al. A nationally representative study of calcific uremic arteriolopathy risk factors. J Am Soc Nephrol. 2016;27(11):3421–9. doi: 10.1681/ASN.2015091065

Pluznick JL, Zou DJ, Zhang X, Yan Q, Rodriguez-Gil DJ, Eisner C, et al. Functional expression of the olfactory signaling system in the kidney. Proc Natl Acad Sci U S A. 2009;106(6):2059–64. doi: 10.1073/pnas.0812859106

Griep M, Van der Niepen P, Sennesael J, Mets T, Massart D, Verbeelen L. Odour perception in chronic renal disease. Nephrol Dial Transplant. 1997;12(10):2093–8. doi: 10.1093/ndt/12.10.2093

Landis BN, Marangon N, Saudan P, Hugentobler M, Giger R, Martin PY, et al. Olfactory function improves following hemodialysis. Kidney Int. 2011;80(8):886–93. doi: 10.1038/ki.2011.189

Koseoglu S, Derin S, Huddam B, Sahan M. The effect of non-diabetic chronic renal failure on olfactory function. Eur Ann Otorhinolaryngol Head Neck Dis. 2017;134(3):161–4. doi: 10.1016/j.anorl.2016.04.022

Frasnelli JA, Temmel AF, Quint C, Oberbauer R, Hummel T. Olfactory function in chronic renal failure. Am J Rhinol. 2002;16(5):275–9.

Kobal G, Klimek L, Wolfensberger M, Gudziol H, Temmel A, Owen CM, et al. Multicenter investigation of 1,036 subjects using a standardized method for the assessment of olfactory function combining tests of odor identification, odor discrimination, and olfactory thresholds. Eur Arch Oto-Rhino-Laryngology. 2000;257(4):205–11. doi: 10.1007/s004050050223

Correa M, Laing DG, Hutchinson I, Jinks AL, Armstrong JE, Kainer G. Reduced taste function and taste papillae density in children with chronic kidney disease. Pediatr Nephrol. 2015;30(11):2003–10. doi: 10.1007/s00467-015-3131-5

Raff AC, Lieu S, Melamed ML, Quan Z, Ponda M, Meyer TW, et al. Relationship of Impaired Olfactory Function in ESRD to Malnutrition and Retained Uremic Molecules. Am J Kidney Dis. 2008;52(1):102–10. doi: 10.1053/j.ajkd.2008.02.301

Márquez-Herrera RM, Núñez-Murillo GK, Ruíz-Gurrola CG, Gómez-García EF, Orozco-González CN, Cortes-Sanabria L, et al. Clinical Taste Perception Test for Patients With End-Stage Kidney Disease on Dialysis. J Ren Nutr. 2020;30(1):79–84. doi: 10.1053/j.jrn.2019.02.003

Manley KJ, Haryono RY, Keast RSJ. Taste changes and saliva composition in chronic kidney disease. Ren Soc Australas J. 2012;8(2):56–60.

Kim TH, Kim YH, Bae NY, Kang SS, Lee JB, Kim SB. Salty taste thresholds and preference in patients with chronic kidney disease according to disease stage: A cross-sectional study. Nutr Diet. 2018;75(1):59–64. doi: 10.1111/1747-0080.12374

Kusaba T, Mori Y, Masami O, Hiroko N, Adachi T, Sugishita C, et al. Sodium restriction improves the gustatory threshold for salty taste in patients with chronic kidney disease. Kidney Int. 2009;76(6):638–43. doi: 10.1038/ki.2009.214

Middleton RA, Allman-Farinelli MA. Taste sensitivity is altered in patients with chronic renal failure receiving continuous ambulatory peritoneal dialysis. J Nutr. 1999;129(1):122–5. doi: 10.1093/jn/129.1.122

Lynch KE, Lynch R, Curhan GC, Brunelli SM. Prescribed Dietary Phosphate Restriction and Survival among Hemodialysis Patients. Clin J Am Soc Nephrol. 2011;6(3):620–9. doi: 10.2215/CJN.04620510

Rico Hernández MA, Viñuela IC, Gómez Gómez-Lobo E, Gómez JD. La malnutrición como causa y consecuencia de distorsiones sensoriales. Nutr Hosp Supl. 2011;4(2):25–30.

Sekine H, Takao K, Yoshinaga K, Kokubun S, Ikeda M. Effects of zinc deficiency and supplementation on gene expression of bitter taste receptors (TAS2Rs) on the tongue in rats. Laryngoscope. 2012;122(11):2411–7. doi: 10.1002/lary.23378

Published

2023-08-28

How to Cite

Carrillo-Degollado, . A. N. ., Salazar-Guzmán, E. P. ., Gutierrez-Pliego, L. E. ., & Orozco-González, C. N. (2023). Alterations in the sense of smell and taste in patients with chronic renal disease, transplant and dialysis and their association with nutritional status. Journal Clinical Nutrition and Metabolism, 6(3), 44–51. https://doi.org/10.35454/rncm.v6n3.500