Nutritional assessment and treatment in patients with acute pancreatitis: Observational study at the “Alejandro Posadas National Hospital”

Authors

  • Clarisa Real hospital posadas
  • Pilar Navarro
  • Eliana Gómez
  • Marisa Canicoba

DOI:

https://doi.org/10.35454/rncm.v5n4.423

Keywords:

Pancreatitis aguda, Evaluación nutricional, Terapia nutricional

Abstract

 Introduction: Acute pancreatitis is a highly metabolic disease. An early initiation of feeding can self-limit catabolism and lead to better outcomes. The characteristics of the nutritional treatment implemented in hospitalized patients in Argentina are unknown. 

Objectives: To report on the nutritional status and the characteristics of the nutritional therapy implemented in patients with acute pancreatitis admitted to the Alejandro Posadas National Hospital, and to analyze the association between nutritional status and severity of acute pancreatitis, its complications, the use of nutritional therapy, and length of hospital stay. 

Methods: Descriptive cross-sectional study. A database with data collected from October 2019 to October 2021 at a third level hospital in Buenos Aires was used. A descriptive analysis of the variables was carried out and Kendall’s Tau b test was used to assess association (p < 0.05). 

Results: A sample of 55 patients was obtained, 70.9% female with a median age of 40 years. Overall, 81.8% of the acute pancreatitis cases were mild, 49.1% had malnutrition, associated with acute pancreatitis severity (p < 0.001), the onset of complications (p < 0.001), and use of nutritional therapy (p < 0.002) but not with length of stay (p 0.16). Body mass 

index was not associated with any of the variables mentioned above. Overall, 71% started late feeding. 14.5% received enteral nutrition and 7.2% received parenteral nutrition during hospitalization. 

Conclusions: Malnutrition is common in patients with acute pancreatitis. Frequently, feeding was initiated late. Patients with malnutrition developed a more severe disease, more complications and required nutritional therapy more frequently. 

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References

Giudi M, Curvale C, Pasqua A, Hwang H, Pires H, Basso S, et al. Actualización en el manejo inicial de la pancreatitis aguda. Acta Gastroenterol Latinoam. 2019;49(4):307-23.

Mayerle J, Sandler M, Hegyi E, Beyer G, Lerch M, Sahin-Tòh M. Genetics and pathophysiology of pancreatitis. Gastroenterology 2019;156(7):1951-68.e1. doi: 10.1053/j.gastro.2018.11.081.

Ocampo C, Kohan G, Leiro F, Basso S, Gutiérrez S, Perna L, et al. Diagnóstico y tratamiento de la pancreatitis aguda en la Argentina. Resultado de un estudio prospectivo en 23 centros. Acta Gastroenterol Latinoam. 2015;45(4):295-302.

Arvanitakis M, Ockenga J, Bezmarevic M, Gianotti L, Krznaric Z, Lobo DN, et al. ESPEN guideline clinical nutrition in acute and chronic pancreatitis. Clin Nutr. 2020;39(3):612-31. doi: 10.1016/j.clnu.2020.01.004.

Mederos M, Reber H, Girgis M. Acute pancreatitis: a review. JAMA. 2021;325(4):382-90. doi: 10.1001/jama.2020.20317.

Crockett SD, Wani S, Gardner TB, Falck-Ytter Y, Barkun AN; American Gastroenterological Association Institute Clinical Guidelines Committee. American Gastroenterological Association Institute Guideline on initial management of acute pancreatitis. Gastroenterology. 2018;154(4):1096-101. doi: 10.1053/j.gastro.2018.01.032.

Tenner S, Baillie J, DeWitt J, Vege SS; American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108(9):1400-15. doi: 10.1038/ajg.2013.218.

Roberts KM, Nahikian-Nelms M, Ukleja A, Lara LF. Nutritional aspects of acute pancreatitis. Gastroenterol Clin North Am. 2018;47(1):77-94. doi: 10.1016/j.gtc.2017.10.002.

Lee PJ, Papachristou GI. Management of severe acute pancreatitis. Curr Treat Options Gastroenterol. 2020;18(4):670-81. doi: 10.1007/s11938-020-00322-x.

Gliem N, Ammer-Herrmenau C, Ellenrieder V, Neesse A. Management of severe acute pancreatitis: an update. Digestion. 2021;102(4):503-7. doi: 10.1159/000506830.

Kanthasamy KA, Aksintala VS, Singh VK. Nutritional management of acute pancreatitis. Gastroenterol Clin North Am. 2021;50(1):141-50. doi: 10.1016/j.gtc.2020.10.014.

Machicado JD, Wani S, Quingalahua E, Han S, Simon V, Hegyi P, et al. Practice patterns and adherence nutrition guidelines in acute pancreatitis: an International Physician Survey. Pancreatology. 2021;21(3):642-8. doi: 10.1016/j.pan.2021.01.001.

Besselink M, van Santvoort H, Freeman M, Gardner T, Mayerle J, Vege SS, et al. IAP/APA evidence-based guidelines forth management of acute pancreatitis. Pancreatology. 2013;13(4):E1-E15. doi: 10.1016/j.pan.2013.07.063.

Perbtani Y, Forsmark CE. Update on the diagnosis and management of exocrine pancreatic insufficiency. F1000Res. 2019;8:F1000 Faculty Rev-1991. doi: 10.12688/f1000research.20779.1.

Canicoba M, de Nobili L, Villagra A. Actualización en el manejo nutricional de la insuficiencia pancreática exocrina: revisión de la literatura. Rev Nutr Clín Metabol. 2021;4(3):62-72. doi: 10.35454/rncm.v4n3.282.

Basso S, Canicoba M, Capitanich P, Carballido M, Crisc IJ, Della Giustina F. I Consenso argentino de diagnóstico y tratamiento de la insuficiencia pancreática exocrina. Acta Gastroenterol Latinoam. 2018;48(3):213-25.

Phillips ME, Hopper AD, Leeds JS, Roberts KJ, McGeeney L, Duggan SN, et al. Consensus for the management of pancreatic exocrine insufficiency: UK practical guidelines. BMJ Open Gastroenterol. 2021;8(1):e000643. doi: 10.1136/bmjgast-2021-000643.

Baron TH, DiMaio CJ, Wang AY, Morgan KA. American Gastroenterological Association Clinical Practice Update: management of pancreatic necrosis. Gastroenterology. 2020;158(1):67-75.e1. doi: 10.1053/j.gastro.2019.07.064.

Yong L, Lu QP, Liu SH, Fan H. Efficacy of glutamine-enriched nutrition support for patients with severe acute pancreatitis: a meta-analysis. J Parenter Enteral Nutr. 2016;40(1):83-94. doi: 10.1177/0148607115570391.

Papachristou G, Machicado JD, Stevens T, Goenka MK, Ferreira M, Gutiérrez SC, et al. Acute pancreatitis patient registry to examine novel therapies in clinical experience (APPRENTICE): an international, multicenter consortium for the study of acute pancreatitis. Ann Gastroenterol. 2017;30(1):106-13. doi: 10.20524/aog.2016.0109.

Márta K, Szabó AN, Pécsi D, Varjú P, Bajor J, Gódi S, et al. High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial. BMJ Open. 2017;7(9):e015874. doi: 10.1136/bmjopen-2017-015874.

Márta K, Farkas N, Szabó I, Illés A, Vincze Á, Pár G, et al. Meta-analysis of early nutrition: the benefits of enteral feeding compared to a nil per os dietnotonly in severe, butalso in mild and moderate acute pancreatitis. Int J Mol Sci. 2016;17(10):1691. doi: 10.3390/ijms17101691.

Evans DC, Corkins MR, Malone A, Miller S, Mogensen KM, Guenter P, et al. The use of visceral proteins as nutrition markers: an ASPEN position paper. Nutr Clin Pract. 2021;36(1):22-8. doi: 10.1002/ncp.10588.

Song J, Zhong Y, Lu X, Kang X, Wang Y, Guo W, et al. Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: a systematic review and meta-analysis. Medicine (Baltimore). 2018;97(34):e11871. doi: 10.1097/MD.0000000000011871.

Murphy AE, Codner PA. Acute pancreatitis: exploring nutrition implications. Nutr Clin Pract. 2020;35(5):807-17. doi: 10.1002/ncp.10479.

Boxhoorn L, Voermans RP, Bouwense SA, Bruno MJ, Verdonk RC, Boermeester MA, et al. Acute pancreatitis. Lancet. 2020;396(10252):726-34. doi: 10.1016/S0140-6736(20)31310-6.

Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102-11. doi: 10.1136/gutjnl-2012-302779.

Gianotti L, Sandini M. Reply to: Re: Nutritional support and therapy in pancreatic surgery: A position paper of the International Study Group on Pancreatic Surgery (ISGPS). Surgery. 2019;165(6):1249. doi: 10.1016/j.surg.2019.01.022.

Gomes CA, Di Saverio S, Sartelli M, Segallini E, Cilloni N, Pezzilli R, et al. Severe acute pancreatitis: eight fundamental steps revised according the ‘PANCREAS’ acronym. Ann R Coll Surg Engl. 2020;102(8):555-9. doi: 10.1308/rcsann.2020.0029.

Detsky AS, McLaughlin JR, Baker JP, Johnston N, Whittaker S, Mendelson RA, et al. What is subjective global assessment of nutritional status? 1987. Nutr Hosp. 2008;23(4):400-7. doi: 10.1097/01.mco.0000222109.53665.ed.

World Health Organization. Global database on body mass index [Internet]. Disponible en: https://www.who.int/data/gho/data/themes/topics/topic-details/GHO/body-mass-index

Arvanitakis M, Gkolfakis P, Fernandez, Viesca M. Nutrition in acute pancreatitis. Curr Opin Clin Nutr Metab Care. 2021;24(5):428-32. doi: 10.1097/MCO.0000000000000776.

Caamaño D, Ocampo C, Alonso F, Zandalazini H, Coturel A, Leyton V, at al. La obesidad y el riesgo de pancreatitis aguda grave. Acta Gastroenterol Latinoam. 2018;48(3):190-6.

Zhou J, Xue Y, Liu Y, Li XK, Tong ZH, Li WQ. The effect of inmunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. J Hum Nutr Diet. 2021;34(2):429-39. doi: 10.1111/jhn.12816.

Hollemans RA, Hallensleben NDL, Mager DJ, Kelder JC, Besselink MG, Bruno MJ, et al. Pancreatic exocrine insufficiency following acute pancreatitis: systematic review and study level meta-analysis. Pancreatology. 2018;18(3):253-62. doi: 10.1016/j.pan.2018.02.009.

Published

2022-12-08

How to Cite

Real, C., Navarro, P., Gómez, E., & Canicoba, M. (2022). Nutritional assessment and treatment in patients with acute pancreatitis: Observational study at the “Alejandro Posadas National Hospital”. Journal Clinical Nutrition and Metabolism, 5(4), 30–37. https://doi.org/10.35454/rncm.v5n4.423