Perfil nutricional e metabólico de pacientes com COVID-19 crítico em uma unidade de terapia intensiva
DOI:
https://doi.org/10.35454/rncm.v6n2.460Palavras-chave:
Distúrbios nutricionais, doenças metabólicas, síndrome do desconforto respiratório, COVID-19, unidade de terapia intensivaResumo
Introdução: a desnutrição está associada à gravidade e mortalidade da COVID-19.
Objetivo: descrever as características e resultados nutricionais e metabólicos de pacientes com COVID-19 crítico.
Métodos: estudo observacional e retrospectivo de pacientes com COVID-19 crítico tratados com ventilação mecânica (VM) em uma unidade de terapia intensiva no Peru. Foram incluídos pacientes com idade ≥18 anos, COVID-19 confirmado e critérios de síndrome do desconforto respiratório moderado ou grave, excluindo pacientes com COVID-19 anterior. A avaliação nutricional e metabólica incluiu: presença de obesidade e diabetes mellitus; escore NUTRIC modificado; valores de: glicose, albumina e bilirrubina total; se você necessitou de insulina; o uso de relaxante muscular e VM em pronação. As variáveis foram apresentadas em frequências absolutas e percentuais, medidas de tendência central com suas dispersões; as variáveis entre vivos e falecidos foram comparadas considerando p <0,05 como significativo.
Resultados: foram incluídos 35 pacientes, com média de idade de 49,1±12,9 anos, sexo masculino predominante (71,4%). Obesidade e diabetes mellitus foram as comorbidades mais frequentes (51,4% e 22,9%, respectivamente), 11,4% apresentavam alto risco nutricional. Os valores médios de glicemia foram 146,60±46,98 mg/dL, albumina 3,26±0,38 mg/dL e bilirrubina total 0,58±0,22 mg/ dL. A dexametasona foi utilizada em 91,4%, insulinoterapia em 20%, relaxante muscular em 94,3% e VM prona em 82,9%.
Conclusões: obesidade, diabetes mellitus, hiperglicemia e hipoalbuminemia foram as características mais relevantes em pacientes com COVID-19 crítico. O escore de risco nutricional e a frequência de pacientes de alto risco nutricional, pelo NUTRIC modificado, foram baixos.
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Referências
Bermúdez C, Pereira FJ, Trejos D, Pérez A, Puentes Sanchez M, López Basto LM, et al. Recomendaciones nutricionales de la Asociación Colombiana de Nutrición Clínica para pacientes hospitalizados con infección por SARS-CoV-2. Revista De Nutrición Clínica Y Metabolismo. 2020;3(1):74–85. doi: 10.35454/rncm.v3n1.066
Mayta-Tristán, P. Los tsunamis por COVID-19 en Perú: El primero malo, segundo peor. Revista Del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo. 2021;14(3):260-261. doi: 10.35434/rcmhnaaa.2021.143.1249
World Health Organization. COVID-19 clinical management. Living guidance 25 january 2021 [internet]. WHO 2021 [Fecha de consulta: el 13 de junio de 2021]. Disponible en: https://apps.who.int/iris/handle/10665/338871.
Barazzoni R, Bischoff SC, Breda J, Wickramasinghe K, Krznaric Z, Nitzan D, et al. ESPEN expert statements and practical guidance for nutritional management of individuals with SARS-CoV-2 infection. Clin Nutr. 2020;39(6):1631-1638.
doi: 10.1016/j.clnu.2020.03.022.
Barazzoni R, Breda J, Cuerda C, Schneider S, Deutz NE, Wickramasinghe K. COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers. Clin Nutr. 2022 Aug 11:S0261-5614(22)00277-1.
doi: 10.1016/j.clnu.2022.07.033.
Chapple LS, Tatucu-Babet OA, Lambell KJ, Fetterplace K, Ridley EJ. Nutrition guidelines for critically ill adults admitted with COVID-19: Is there consensus? Clin Nutr ESPEN. 2021;44:69-77.
doi: 10.1016/j.clnesp.2021.05.003.
Eden T, McAuliffe S. Critical care nutrition and COVID-19: a cause of malnutrition not to be underestimated. BMJ Nutrition, Prevention & Health. 2021;4:e000271. doi:10.1136/bmjnph-2021-000271
Rahman A, Hasan RM, Agarwala R, Martin C, Day AG, Heyland DK. Identifying critically-ill patients who will benefit most from nutritional therapy: Further validation of the "modified NUTRIC" nutritional risk assessment tool. Clin Nutr. 2016;35(1):158-162. doi: 10.1016/j.clnu.2015.01.015.
Ziehr DR, Alladina J, Petri CR, Maley JH, Moskowitz A, Medoff BD, et al. Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19: A Cohort Study. Am J Respir Crit Care Med. 2020;201(12):1560-1564.
doi: 10.1164/rccm.202004-1163LE.
Søvik S, Bådstøløkken PM, Sørensen V, Myhre PL, Prebensen C, Omland T, et al. A single-centre, prospective cohort study of COVID-19 patients admitted to ICU for mechanical ventilatory support. Acta Anaesthesiol Scand. 2021;65:351–359.
doi: 10.1111/aas.13726.
Krause M, Douin DJ, Kim KK, Fernandez-Bustamante A, Bartels K. Characteristics and Outcomes of Mechanically Ventilated COVID-19 Patients—An Observational Cohort Study. Journal of Intensive Care Medicine. 2021;36(3) 271-276.
doi: 10.1177/0885066620954806.
Dessie ZG, Zewotir T. Mortality-related risk factors of COVID-19: a systematic review and meta-analysis of 42 studies and 423,117 patients. BMC Infect Dis. 2021;21(1):855. doi: 10.1186/s12879-021-06536-3.
Du Y, Lv Y, Zha W, Zhou N, Hong X. Association of body mass index (BMI) with critical COVID-19 and in-hospital mortality: A dose-response meta-analysis. Metabolism. 2021;117:154373. doi: 10.1016/j.metabol.2020.154373.
Li Y, Ashcroft T, Chung A, Dighero I, Dozier M, Horne M, et al. Risk factors for poor outcomes in hospitalised COVID-19 patients: A systematic review and meta-analysis. J Glob Health. 2021;11:10001. doi: 10.7189/jogh.11.10001.
Ñamendys-Silva SA, Alvarado-Avila PE, Domínguez-Cherit G, Rivero-Sigarroa E, Sanchez-Hurtado LA, Gutierrez-Villaseñor A, et al. Outcomes of patients with COVID-19 in the intensive care unit in Mexico: A multicenter observational study. Heart Lung. 2021;50:28-32. doi: 10.1016/j.hrtlng.2020.10.013.
Lobo-Valbuena B, García-Arias M, Pérez RB, Delgado DV, Gordo F. Characteristics of critical patients with COVID-19 in a Spanish second-level hospital. Med Intensiva (Engl Ed). 2021;45(1):56-58. doi: 10.1016/j.medin.2020.06.020
Reis AMD, Fructhenicht AVG, Moreira LF. NUTRIC score use around the world: a systematic review. Rev Bras Ter Intensiva. 2019;31(3):379-385. doi: 10.5935/0103-507X.20190061.
Kumar N, Kumar A, Kumar A, Pattanayak A, Singh K, Singh PK. NUTRIC score as a predictor of outcome in COVID-19 ARDS patients: A retrospective observational study. Indian J Anaesth. 2021;65(9):669-675. doi: 10.4103/ija.ija_474_21.
Bodolea C, Nemes A, Avram L, Craciun R, Coman M, Ene-Cocis M, et al. Nutritional Risk Assessment Scores Effectively Predict Mortality in Critically Ill Patients with Severe COVID-19. Nutrients. 2022;14(10):2105. doi: 10.3390/nu14102105.
Zhang P, He Z, Yu G, Peng D, Feng Y, Ling J, et al. The modified NUTRIC score can be used for nutritional risk assessment as well as prognosis prediction in critically ill COVID-19 patients. Clin Nutr. 2021;40(2):534-541. doi: 10.1016/j.clnu.2020.05.051.
Leoni MLG, Moschini E, Beretta M, Zanello M, Nolli M. The modified NUTRIC score (mNUTRIC) is associated with increased 28-day mortality in critically ill COVID-19 patients: Internal validation of a prediction model. Clin Nutr ESPEN. 2022;48:202-209. doi: 10.1016/j.clnesp.2022.02.014.
Palermo Dos Santos AC, Japur CC, Passos CR, Lunardi TCP, Lovato WJ, Pena GDG. Nutritional risk, not obesity, is associated with mortality in critically ill COVID-19 patients. Obes Res Clin Pract. 2022;16(5):379-385. doi: 10.1016/j.orcp.2022.08.005.
Martinuzzi ALN, Manzanares W, Quesada E, Reberendo MJ, Baccaro F, Aversa I, et al. Nutritional risk and clinical outcomes in critically ill adult patients with COVID-19. Nutr Hosp. 2021;38(6):1119-1125. English. doi: 10.20960/nh.03749.
Liberti A, Piacentino E, Umbrello M, Muttini S. Comparison between Nutric Score and modified nutric score to assess ICU mortality in critically ill patients with COVID-19. Clin Nutr ESPEN. 2021;44:479-482. doi: 10.1016/j.clnesp.2021.04.026.
Douin DJ, Krause M, Williams C, Tanabe K, Fernandez-Bustamante A, et al. Corticosteroid Administration and Impaired Glycemic Control in Mechanically Ventilated COVID-19 Patients. Semin Cardiothorac Vasc Anesth. 2022;26(1):32-40.
doi: 10.1177/10892532211043313.
Huang J, Cheng A, Kumar R, Fang Y, Chen G, Zhu Y, et al. Hypoalbuminemia predicts the outcome of COVID-19 independent of age and co-morbidity. J Med Virol. 2020;92(10):2152-2158. doi: 10.1002/jmv.26003.
Aziz M, Fatima R, Lee-Smith W, Assaly R. The association of low serum albumin level with severe COVID-19: a systematic review and meta-analysis. Crit Care. 2020 ;24(1):255. doi: 10.1186/s13054-020-02995-3.
Liu Z, Li J, Long W, Zeng W, Gao R, Zeng G, et al. Bilirubin Levels as Potential Indicators of Disease Severity in Coronavirus Disease Patients: A Retrospective Cohort Study. Front Med (Lausanne). 2020;7:598870. doi: 10.3389/fmed.2020.598870.
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