How to feed the patient in palliative care? A narrative review

Authors

DOI:

https://doi.org/10.35454/rncm.v4n2.243

Keywords:

Nutrition, Parenteral nutrition, Palliative care

Abstract

Malnutrition is a common condition in patients with incurable diseases who benefit from palliative care. Nutritional care, a fundamental component in the treatment of these patients, allows the adequate administration of oral, enteral, or parenteral nutritional therapy. In this context, nutritional therapy is indicated to increase survival and quality of life in some patients, such as those with neurological diseases or cancer. However, there is still a lot of controversy over its indications and potential benefits, particularly of home parenteral nutrition. Therefore, the aim of this review is to answer two questions: When should nutrition therapy be started and when should it be stopped? Does nutritional therapy improve the quality of life and prolong survival of palliative care patients? Scientific societies do not recommend the use of nutritional therapy in all cases of malnutrition, especially in patients with hypophagia whose life expectancy is less than 2 months. Parenteral nutrition may benefit some well identified patients by increasing survival. However, the impact on quality of life remains uncertain.

Decisions must be made individually, respecting the patient’s autonomy, and avoiding therapeutic viciousness. Research in this field must advance to determine with greater certainty the risk-benefit ratio of nutritional therapy.

Downloads

Download data is not yet available.

References

Cuidados paliativos [Internet]. Organización Mundial de la Salud. 2020. (Consultado el 4 de octubre 2020). Disponible en: https://www.who.int/es/news-room/fact-sheets/detail/palliative-care

von Haehling S, Anker SD. Prevalence, incidence and clinical impact of cachexia: facts and numbers-update. J Cachexia Sarcopenia Muscle. 2014;5:261-3. doi: 10.1007/s13539-014-0164-8.

Ryan AM, Power DG, Daly L, Cushen SJ, Ní Bhuachalla Ē, Prado CM. Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later. Proc Nutr Soc. 2016;75(2):199-211. doi: 10.1017/S002966511500419X-

Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489-95. doi: 10.1016/S1470-2045(10)70218-7.

Cederholm T, Barazzoni R, Austin P, Ballmer P, Biolo G, Bischoff SC, et al. ESPEN guidelines on definitions and terminology of clinical nutrition. Clin Nutr. 2017;36(1):49-64. doi: 10.1016/j.clnu.2016.09.004.

Ukleja A, Gilbert K, Mogensen KM, Walker R, Ward CT, Ybarra J, et al. Standards for nutrition support: adult hospitalized patients. Nutr Clin Pract. 2018;33(6):906-20. doi: 10.1002/nCP.10204.

Schuetz P, Fehr R, Baechli V, Geiser M, Deiss M, Gomes F, et al. Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial. Lancet. 2019;8;393(10188):2312-21. doi: 10.1016/S0140-6736(18)32776-4.

Druml C, Ballmer PE, Druml W, Oehmichen F, Shenkin A, Singer P, et al. ESPEN guideline on ethical aspects of artificial nutrition and hydration. Clin Nutr. 2016;35(3):545-56. doi: 10.1016/j.clnu.2016.02.006.

Bozzetti F. Is there a place for nutrition in palliative care? Support Care Cancer. 2020;28(9):4069-75. doi: 10.1007/s00520-020-05505-x.

Bozzetti F. Nutrition, hydration, and patient’s preferences at the end of life. Support Care Cancer. 2015;23:14878. doi: 10.1007/s00520-014-2591-7.

Bükki J, Unterpaul T, Nübling G, Jox RJ, Lorenzl S. Decision making at the end of life--cancer patients’ and their caregivers’ views on artificial nutrition and hydration. Support Care Cancer. 2014;22(12):3287-99. doi: 10.1007/s00520-014-2337-6.

Naghibi M, Smith TR, Elia M. A systematic review with meta-analysis of survival, quality of life and cost-effectiveness of home parenteral nutrition in patients with inoperable malignant bowel obstruction. Clin Nutr. 2015;34(5):825-37. doi: 10.1016/j.clnu.2014.09.010.

Sowerbutts AM, Lal S, Sremanakova J, Clamp A, Todd C, Jayson GC, et al. Home parenteral nutrition for people with inoperable malignant bowel obstruction. Cochrane Database Syst Rev. 2018;8(8):CD012812. doi: 10.1002/14651858.CD012812.pub2.

Bozzetti F. The role of parenteral nutrition in patients with malignant bowel obstruction. Support Care Cancer. 2019;27:4393-9. https://doi.org/10.1007/s00520-019-04948.

Keane N, Fragkos KC, Patel PS, Bertsch F, Mehta SJ, Di Caro S, et al. Performance status, prognostic scoring, and parenteral nutrition requirements predict survival in patients with advanced cancer receiving home parenteral nutrition. Nutr Cancer. 2018;70(1):73-82. doi: 10.1080/01635581.2018.1380206.

Theilla M, Cohen J, Kagan I, Attal-Singer J, Lev S, Singer P. Home parenteral nutrition for advanced cancer patients: contributes to survival? Nutrition. 2018;54:197-200. doi: 10.1016/j.nut.2017.03.005.

Aría Guerra E, Cortés-Salgado A, Mateo-Lobo R, Nattero L, Riveiro J, Vega-Piñero B, et al. Role of parenteral nutrition in oncologic patients with intestinal occlusion and peritoneal carcinomatosis. Nutr hosp. 2015;32(3):1222-7. doi: 10.3305/nh.2015.32.3.9184.

Bozzetti F, Santarpia L, Pironi L, Thul P, Klek S, Gavazzi C, et al. The prognosis of incurable cachectic cancer patients on home parenteral nutrition: a multi-centre observational study with prospective follow-up of 414 patients. Ann Oncol. 2014;25(2):487-93. doi: 10.1093/annonc/mdt549.

Chermesh I, Mashiach T, Amit A, Haim N, Papier I, Efergan R, et al. Home parenteral nutrition (HTPN) for incurable patients with cancer with gastrointestinal obstruction: do the benefits outweigh the risks? Med Oncol. 2011;28(1):83-8. doi: 10.1007/s12032-010-9426-2.

Soo I, Gramlich L. Use of parenteral nutrition in patients with advanced cancer. Appl Physiol Nutr Metab. 2008;33(1):102-6. doi: 10.1139/H07-152.

Fan BG. Parenteral nutrition prolongs the survival of patients associated with malignant gastrointestinal obstruction. JPEN J Parenter Enter Nutr. 2007;31(6):508-10. doi: 10.1177/0148607107031006508.

Wang MY, Wu MH, Hsieh DY, Lin LJ, Lee PH, Chen WJ, et al. Home parenteral nutrition support in adults: experience of a medical center in Asia. JPEN J Parenter Enteral Nutr. 2007;31(4):306-10. doi: 10.1177/0148607107031004306.

Santarpia L, Alfonsi L, Pasanisi F, De Caprio C, Scalfi L, Contaldo F. Predictive factors of survival in patients with peritoneal carcinomatosis on home parenteral nutrition. Nutrition. 2006;22(4):355-60. doi: 10.1016/j.nut.2005.06.011.

Hoda D, Jatoi A, Burnes J, Loprinzi C, Kelly D. Should patients with advanced, incurable cancers ever be sent home with total parenteral nutrition? A single institution’s 20-year experience. Cancer. 2005;103(4):863-8. doi: 10.1002/cncr.20824. PMID: 15641035.

Teunissen SC, Wesker W, Kruitwagen C, de Haes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: a systematic review. J Pain Symptom Manage. 2007;34(1):94-104. doi: 10.1016/j.jpainsymman.2006.10.015.

Bozzetti F. Parenteral nutrition. Nutrition. 2019;66:101-7. doi: 10.1016/j.nut.2019.03.013.

Bolt EE, Hagens M, Willems D, Onwuteaka-Philipsen BD. Primary care patients hastening death by voluntarily stopping eating and drinking. Ann Fam Med. 2015;13(5):421-8. doi: 10.1370/afm.1814.

Oh SY, Jun HJ, Park SJ, Park IK, Lim GJ, Yu Y, et al. A randomized phase II study to assess the effectiveness of fluid therapy or intensive nutritional support on survival in patients with advanced cancer who cannot be nourished via enteral route. J Palliat Med. 2014;17(11):1266-70. doi: 10.1089/jpm.2014.0082.

Hamano J, Kizawa Y, Maeno T, Nagaoka H, Shima Y, Maeno T. Prospective clarification of the utility of the palliative prognostic index for patients with advanced cancer in the home care setting. Am J Hosp Palliat Care. 2014;31(8):820-4. doi: 10.1186/s12904-020-00676-0

Hui D. Prognostication of survival in patients with advanced cancer: predicting the unpredictable? Cancer Control. 2015;22(4):489-97. doi: 10.1177/107327481502200415.

Hung CY, Wang HM, Kao CY, Lin YC, Chen JS, Hung YS, et al. Magnitude of score change for the palliative prognostic index for survival prediction in patients with poor prognostic terminal cancer. Support Care Cancer. 2014;22(10):2725-31. doi: 10.1007/s00520-014-2274-4.

Bozzetti F, Cotogni P, Lo Vullo S, Pironi L, Giardiello D, Mariani L. Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition. Ann Oncol. 2015;26(11):2335-40. doi: 10.1093/annonc/mdv365.

Cotogni P, Monge T, Passera R, Brossa L, De Francesco A. Clinical characteristics and predictive factors of survival of 761 cancer patients on home parenteral nutrition: a prospective cohort study. Cancer Med. 2020;9(13):4686-98. doi: 10.1002/cam4.3064.

Bozzetti F, Arends J, Lundholm K, Micklewright A, Zurcher G, Muscaritoli M, et al. ESPEN Guidelines on Parenteral Nutrition: non-surgical oncology. Clin Nutr. 2009;28(4):445-54. doi: 10.1016/j.clnu.2009.04.011.

Bozzetti F, Cozzaglio L, Biganzoli E, Chiavenna G, De Cicco M, Donati D, et al. Quality of life and length of survival in advanced cancer patients on home parenteral nutrition. Clin Nutr. 2002;21(4):281-8. doi: 10.1054/clnu.2002.0560.

Beijer S, Vogel J, Jager-Wittenaar H. Alternative terminology for the confusing term “palliative nutrition”. Clin Nutr. 2017;36(6):1723-4. doi: 10.1016/j.clnu.2017.09.012.

Indicación médica [internet]. Real Academia Nacional de Medicina de España. (Consultado el 1 de noviembre de 2020) Disponible en: https://dtme.ranm.es/buscador.aspx?NIVEL_BUS=3&LEMA_BUS=indicaci%C3%B3n

Cárdenas D, Bermúdez CE, Echeverri S, Pérez A, Puentes M, López L, et al. Declaración de Cartagena. Declaración Internacional sobre el Derecho al Cuidado Nutricional y la Lucha contra la Malnutrición. Nutr Hosp. 2019;36(4):974-80. doi: 10.20960/nh.02701.

Cardenas D, Dumas F. Aspects éthiques de la nutrition artificielle en réanimation et soins intensifs. En QNC en réanimation et soins intensif. SFNCM. 2019. p. 223-39.

Published

2020-12-16

How to Cite

Cárdenas, D. (2020). How to feed the patient in palliative care? A narrative review. Journal Clinical Nutrition and Metabolism, 4(2). https://doi.org/10.35454/rncm.v4n2.243