Vitamina D a la admisión y severidad de la enfermedad en pacientes con COVID-19 en la Unidad de Cuidados Intensivos

Autores/as

  • Victoria Gonzalez Mgtr.
  • Cayetano Galletti Med.
  • Romina Alvarez Vizzoni Med.
  • Yanina Saldivar Med.
  • Nicolás Kessler Med.
  • Francisco Irades Med.
  • Estefanía Minoldo Med.
  • Pablo Calcagno Med.
  • Antonella Aliscioni Med.
  • Ursula Zaya Med.

Palabras clave:

enfermedad Coronavirus 2019, Vitamina D, ventilación mecánica, unidad de cuidados intensivos

Resumen

Introducción: La 25-hidroxivitamina D (25(OH)D) disminuiría la incidencia de infecciones respiratorias virales, por su efecto pleiotrópico en la inmunomodulación.

Objetivo: evaluamos la influencia de la deficiencia severa de 25(OH)D con la severidad de la enfermedad COVID-19.

Métodos: estudio retrospectivo observacional, que incluyó 164 pacientes con diagnóstico de COVID-19 ingresados a la unidad de cuidados intensivos que tuvieran valores plasmáticos de 25(OH)D las primeras 72 horas de internación.

Resultados: exhibieron deficiencia de 25(OH)D (<30 ng/ml) 136 (83%) pacientes y 35 (21%) tuvieron 25(OH)D ≤12 ng/m.  Los pacientes con deficiencia severa de 25(OH)D tuvieron significativamente mayor probabilidad de COVID-19 severo (OR 2.2, IC95% 1.02 a 5.06, p= 0,049) y presentaron mayor probabilidad de requerir asistencia ventilatoria invasiva (OR 2.4, IC95% 1.09 a 5.58, p=0.036). La mortalidad, fue significativamente mayor en el grupo con deficiencia severa de 25(OH)D (40% vs 22%, p=0.03), con un OR 2.4, 95%IC 1.07 a 5.32, p=0.031. En el modelo multivariado, el antecedente de enfermedad cardiovascular, deficiencia severa de 25(OH)D, PaO2/FiO2 y asistencia ventilatoria invasiva, permanecieron significativos.

Conclusión: este estudio confirma que la deficiencia severa de vitamina D se asocia con una afectación pulmonar más grave, una mayor gravedad de la enfermedad y riesgo de muerte en pacientes con COVID-19.

 

 

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Biografía del autor/a

Victoria Gonzalez, Mgtr.

Cayetano Galletti, Med.

Romina Alvarez Vizzoni, Med.

Yanina Saldivar, Med.

Nicolás Kessler, Med.

Francisco Irades, Med.

Estefanía Minoldo, Med.

Pablo Calcagno, Med.

Antonella Aliscioni, Med.

Ursula Zaya, Med.

Citas

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Publicado

2023-03-14

Cómo citar

Gonzalez, V., Galletti, C., Alvarez Vizzoni, R. ., Saldivar, Y., Kessler, N., Irades, F., Minoldo, E. ., Calcagno, P., Aliscioni, A. ., & Zaya, U. (2023). Vitamina D a la admisión y severidad de la enfermedad en pacientes con COVID-19 en la Unidad de Cuidados Intensivos. Revista De Nutrición Clínica Y Metabolismo. Recuperado a partir de https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo/article/view/485

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